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Cleavage, or initial cell division, can only occur in a region called the blastodisc, a yolk free region located at the animal pole of the egg. The fish zygote is meroblastic, meaning the early cell divisions are not complete. This type of meroblastic cleavage is called discoidal because only the blastodisc becomes the embryo. [1]
Zebrafish embryo 48 hours after fertilization. The arrows indicate four Rohon–Beard neurons. [1] Rohon–Beard cells are specialized primary neurons with mechanoreceptive properties. [2] [3] They occur during the embryonic stage of development and are found in the dorsal part of the spinal cord in fishes and amphibians.
In situ hybridization (ISH) is a type of hybridization that uses a labeled complementary DNA, RNA or modified nucleic acid strand (i.e., a probe) to localize a specific DNA or RNA sequence in a portion or section of tissue or if the tissue is small enough (e.g., plant seeds, Drosophila embryos), in the entire tissue (whole mount ISH), in cells ...
Up to 18% of Morpholinos appear to induce nontarget-related phenotypes including cell death in the central nervous system and somite tissues of zebrafish embryos. [43] Most of these effects are due to activation of p53-mediated apoptosis and can be suppressed by co-injection of an anti-p53 Morpholino along with the experimental Morpholino.
The zebrafish (Danio rerio) is a species of freshwater ray-finned fish belonging to the family Danionidae of the order Cypriniformes.Native to South Asia, [3] it is a popular aquarium fish, frequently sold under the trade name zebra danio [4] (and thus often called a "tropical fish" although it is both tropical and subtropical).
The Zebrafish Information Network is an online biological database of information about the zebrafish (Danio rerio). The zebrafish is a widely used model organism for genetic , genomic , and developmental studies, and ZFIN provides an integrated interface for querying and displaying the large volume of data generated by this research. [ 2 ]
This generally involves the action of cytoplasmic determinants, located within parts of the fertilized egg, and of inductive signals emitted from signaling centers in the embryo. The early stages of regional specification do not generate functional differentiated cells, but cell populations committed to developing to a specific region or part ...
12562 Ensembl ENSG00000179776 ENSMUSG00000031871 UniProt P33151 P55284 RefSeq (mRNA) NM_001114117 NM_001795 NM_009868 RefSeq (protein) NP_001786 NP_033998 Location (UCSC) Chr 16: 66.37 – 66.4 Mb Chr 8: 104.83 – 104.87 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cadherin-5, or VE-cadherin (vascular endothelial cadherin), also known as CD144 (C luster of D ifferentiation 144 ...