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This file was derived from: Hiv replication cycle.gif This image has been created during "DensityDesign Integrated Course Final Synthesis Studio" at Polytechnic University of Milan, organized by DensityDesign Research Lab in 2016. Image is released under CC-BY-SA licence. Attribution goes to "Chiara Cirella, DensityDesign Research Lab".
A reverse transcriptase (RT) is an enzyme used to convert RNA genome to DNA, a process termed reverse transcription.Reverse transcriptases are used by viruses such as HIV and hepatitis B to replicate their genomes, by retrotransposon mobile genetic elements to proliferate within the host genome, and by eukaryotic cells to extend the telomeres at the ends of their linear chromosomes.
The p24 capsid protein is the most abundant HIV protein with each virus containing approximately 1,500 to 3,000 p24 molecules. [1] It is the major structural protein within the capsid , and it is involved in maintaining the structural integrity of the virus and facilitating various stages of the viral life cycle, including viral entry into host ...
Reverse-transcriptase inhibitors (RTIs) are a class of antiretroviral drugs used to treat HIV infection or AIDS, and in some cases hepatitis B. RTIs inhibit activity of reverse transcriptase, a viral DNA polymerase that is required for replication of HIV and other retroviruses.
HIV is a retrovirus, which comprise a large and diverse family of RNA viruses that make a DNA copy of their RNA genome after infection of a host cell. An essential step in the replication cycle of HIV-1 and other retroviruses is the integration of this viral DNA into the host DNA. The RNA genome of progeny virions and the template for ...
Research on the development of an HIV-1 vaccine has sought to replicate virus-specific CD8+ T-cell responses, which play a role in the control of HIV-1 replication. [10] Superinfection case reports have shown that superinfecting strains generally had different viral epitopes from the initial infecting cell. [10]
Raltegravir is an INSTI integrase inhibitor which inhibits both HIV-1 and HIV-2 replication. It is more potent than other previously known integrase inhibitors as well as causing less side effects. Raltegravir, Elvitegravir, Dolutegravir, Bictegravir and Cabotegravir are the only HIV-1 integrase inhibitor being used to treat HIV infections S ...
In 1985, HIV was identified as the causative agent of acquired immune deficiency syndrome (AIDS) and its complete genome was immediately available. This knowledge paved the way for the development of selective inhibitors. [6] HIV-2 carries a slightly lower risk of transmission than HIV-1 and infection tends to progress more slowly to AIDS. [7]
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