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The p24 capsid protein is the most abundant HIV protein with each virus containing approximately 1,500 to 3,000 p24 molecules. [1] It is the major structural protein within the capsid , and it is involved in maintaining the structural integrity of the virus and facilitating various stages of the viral life cycle, including viral entry into host ...
HIV is a retrovirus, which comprise a large and diverse family of RNA viruses that make a DNA copy of their RNA genome after infection of a host cell. An essential step in the replication cycle of HIV-1 and other retroviruses is the integration of this viral DNA into the host DNA. The RNA genome of progeny virions and the template for ...
A reverse transcriptase (RT) is an enzyme used to convert RNA genome to DNA, a process termed reverse transcription.Reverse transcriptases are used by viruses such as HIV, COVID-19, and hepatitis B to replicate their genomes, by retrotransposon mobile genetic elements to proliferate within the host genome, and by eukaryotic cells to extend the telomeres at the ends of their linear chromosomes.
Raltegravir is an INSTI integrase inhibitor which inhibits both HIV-1 and HIV-2 replication. It is more potent than other previously known integrase inhibitors as well as causing less side effects. Raltegravir, Elvitegravir, Dolutegravir, Bictegravir and Cabotegravir are the only HIV-1 integrase inhibitor being used to treat HIV infections S ...
This file was derived from: Hiv replication cycle.gif This image has been created during "DensityDesign Integrated Course Final Synthesis Studio" at Polytechnic University of Milan, organized by DensityDesign Research Lab in 2016. Image is released under CC-BY-SA licence. Attribution goes to "Chiara Cirella, DensityDesign Research Lab".
Structure of HIV, a lentivirus. The virions are enveloped viruses 80–100 nm in diameter. [6] They are spherical or pleomorphic, with capsid cores that mature to a cylindrical or conical shape. [6] [7] Projections of envelope make the surface appear rough, or tiny spikes (about 8 nm) may be dispersed evenly over the surface. [6]
Continuous HIV replication results in a state of generalized immune activation persisting throughout the chronic phase. [6] Immune activation, which is reflected by the increased activation state of immune cells and release of proinflammatory cytokines , results from the activity of several HIV gene products and the immune response to ongoing ...
To study the kissing stem-loop loop interaction, It was seen that the Dimerization initiation site (DIS) complex was essential to the replication of the HIV type 1 virus in the eukaryotic cell, and any changes to the stem loop structure diminished the dimerization interaction. Experimentally, it has been seen that, in vivo, mutating the ...