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n/a Ensembl ENSG00000152291 n/a UniProt O43493 n/a RefSeq (mRNA) NM_006464 NM_001206840 NM_001206841 NM_001206844 NM_001368095 NM_001368096 n/a RefSeq (protein) NP_001193769 NP_001193770 NP_001193773 NP_006455 NP_001355024 NP_001355025 n/a Location (UCSC) Chr 2: 85.32 – 85.33 Mb n/a PubMed search n/a Wikidata View/Edit Human Trans-Golgi network integral membrane protein 2 is a protein that ...
Protein targeting or protein sorting is the biological mechanism by which proteins are transported to their appropriate destinations within or outside the cell. [ 1 ] [ 2 ] [ note 1 ] Proteins can be targeted to the inner space of an organelle , different intracellular membranes , the plasma membrane , or to the exterior of the cell via secretion .
Molecules are also transported to endosomes from the trans Golgi network and either continue to lysosomes or recycle back to the Golgi apparatus. Endosomes can be classified as early, sorting, or late depending on their stage post internalization. [1] Endosomes represent a major sorting compartment of the endomembrane system in cells. [2]
The golgins are a family of proteins, of which the protein encoded by this gene is a member, that are localized to the Golgi. This protein has been postulated to play a role in Rab6-regulated membrane-tethering events in the Golgi apparatus. Alternative splice variants have been described but their full-length nature has not been determined. [6]
Since the ER is the site of protein synthesis, it would serve as the parent organelle, and the cis face of the golgi, where proteins and signals are received, would be the acceptor. In order for the transport vesicle to accurately undergo a fusion event, it must first recognize the correct target membrane then fuse with that membrane.
This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this ...
COPI is a coatomer that coats the vesicles transporting proteins from the Golgi complex to the ER. [4] This pathway is referred to as retrograde transport. Before the COP I protein can coat vesicles on the Golgi membrane, it must interact with a small GTPase called ARF1 (ADP ribosylation factor). [5]
Once appropriately marked with the M6P targeting signal, these proteins are moved to the trans-Golgi network. There, the M6P moiety is recognized and bound by mannose 6-phosphate receptor (MPR) proteins at pH 6.5–6.7. [1] The M6P-tagged lysosomal enzymes are shipped to the late endosomes via vesicular transport. [1]