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Sulforaphane (sometimes sulphoraphane in British English) is a compound within the isothiocyanate group of organosulfur compounds. [1] It is produced when the enzyme myrosinase transforms glucoraphanin, a glucosinolate, into sulforaphane upon damage to the plant (such as from chewing or chopping during food preparation), which allows the two compounds to mix and react.
Sulforaphane and other isothiocyanates have been studied for their potential biological effects. [3] The isothiocyanates formed from glucosinolates are under laboratory research to assess the expression and activation of enzymes that metabolize xenobiotics , such as carcinogens . [ 3 ]
Although there has been some basic research on how sulforaphane might exert beneficial effects in vivo, there is no high-quality evidence for its efficacy against human diseases. [ 2 ] [ 3 ] Broccoli sprouts also contain a particular glucosinolate compound, glucoraphanin , which is found in vacuoles within the cytoplasm of the plant cell.
The incidence rate varied from 2% up to 33% — with oral cavity/pharynx cancer representing the highest increase. Additionally, the cancers associated with PFAS-contaminated water also varied by sex.
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