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Unlike the Wolff–Chaikoff effect, the Plummer effect does not prevent the thyroid from taking up radioactive iodine, e.g. in the case of nuclear emergencies.Therefore, "plummering" with high-dose iodine is only effective in a short time window after the release of radionuclides. [9]
Iodine, in non-elemental form, functions as an essential nutrient in human biology (see iodine in biology). [3] Organic compounds containing iodine are also useful iodinated contrast agents in X-ray imaging. [4] Common side effects when applied to the skin include irritation and discoloration. [2]
Iodine-135 is an isotope of iodine with a half-life of 6.6 hours. It is an important isotope from the viewpoint of nuclear reactor physics . It is produced in relatively large amounts as a fission product , and decays to xenon-135 , which is a nuclear poison with the largest known thermal neutron cross section , which is a cause of multiple ...
Radioactive iodine (iodine-131) alone can potentially worsen thyrotoxicosis in the first few days after treatment. One side effect of treatment is an initial period of a few days of increased hyperthyroid symptoms. This occurs because when the radioactive iodine destroys the thyroid cells, they can release thyroid hormone into the blood stream.
Only the Wolff–Chaikoff effect is helpful to prevent the thyroid from uptaking radioactive iodine in the case of nuclear emergencies. Therefore, "plummering" with high-dose iodine is only effective in a short time window after the release of radionuclides. [15] Wrong timing of iodine use may even increase the risk by triggering the Plummer ...
Many of the side effects are due to the hyperosmolar solution being injected. i.e. they deliver more iodine atoms per molecule. The more iodine, the more "dense" the X-ray effect. [citation needed] Organic iodine molecules used for contrast include iohexol, iodixanol, and ioversol. Iodine-based contrast media used nowadays are water-soluble.
In some ways the Jod-Basedow phenomenon is the opposite of two physiological compensation mechanisms, the Plummer effect and the Wolff–Chaikoff effect, which in normal persons and in persons with thyroid disease, suppress the thyroid hormone after ingestion of large quantities of iodine or iodide. However, unlike the Plummer and Wolff ...
Administering the radioactive isotope causes the thyroid to take in the lethal iodine and quickly radiation destroys it. [12] Typically overproduction of thyroxine using radio-iodine is blocked with one dose. The drawback to this treatment is the thyroid gland is completely destroyed and patients often develop hypothyroidism. Some do so only a ...