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It also interacts with SNX27; the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. [19] This protein interacts with STOM. [20] It interacts with SGTA (via Gln-rich region) and has binary interactions with CREB3-2. [4] [5] GLUT1 has two significant types in the brain: 45 ...
Things that can be transported are nutrients, ions, glucose, etc, all depending on the needs of the cell. One example of a uniport mediated transport protein is GLUT1. GLUT1 is a transmembrane protein, which means it spans the entire width of the cell membrane, connecting the extracellular and intracellular region.
The GLUT1 protein that transports glucose across the blood brain barrier is encoded by the SLC2A1 gene, located on chromosome 1. [8] In GLUT1 deficiency syndrome, one of the two genes is damaged by a mutation and an insufficient amount protein is made. As a result, insufficient glucose is passing the blood brain barrier.
Levels in cell membranes are increased by reduced glucose levels and decreased by increased glucose levels. GLUT1 expression is upregulated in many tumors. GLUT2: Is a bidirectional transporter, allowing glucose to flow in 2 directions. Is expressed by renal tubular cells, liver cells and pancreatic beta cells.
GLUT1 is a hydrophobic protein and 50% of GLUT1 is in the lipid bilayer. GLUT1 is present in the placenta, brain, epithelial cells of the mammary gland, transformed cells, and fetal tissue. [5] Due to its ubiquitous presence, it is proposed that GLUT1 is at least somewhat responsible for basal glucose uptake. [5]
3091 15251 Ensembl ENSG00000100644 ENSMUSG00000021109 UniProt Q16665 Q61221 RefSeq (mRNA) NM_181054 NM_001243084 NM_001530 NM_010431 NM_001313919 NM_001313920 RefSeq (protein) NP_001230013 NP_001521 NP_851397 NP_001521.1 NP_001300848 NP_001300849 NP_034561 Location (UCSC) Chr 14: 61.7 – 61.75 Mb Chr 12: 73.95 – 73.99 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Hypoxia ...
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The two halves of the protein pack against each other in a clam-shell fashion, sealing via interactions at the ends of the transmembrane helices and extracellular loops. [ 7 ] [ 8 ] This forms a large aqueous cavity at the center of the membrane, which is alternatively open to the cytoplasm or periplasm /extracellular space.