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Prohibitin-targeting peptide 1 (also known as prohibitin-TP01 and TP01; trade name Adipotide) is a peptidomimetic with sequence CKGGRAKDC-GG-D (KLAKLAK) 2. It is an experimental proapoptotic drug [ 1 ] that has been shown to cause rapid weight loss in mice [ 2 ] and rhesus monkeys. [ 3 ]
A peptidomimetic is a small protein-like chain designed to mimic a peptide. [ 1 ] [ 2 ] They typically arise either from modification of an existing peptide, or by designing similar systems that mimic peptides, such as peptoids and β-peptides .
6564 56643 Ensembl ENSG00000088386 ENSMUSG00000025557 UniProt P46059 Q9JIP7 RefSeq (mRNA) NM_005073 NM_053079 RefSeq (protein) NP_005064 NP_444309 Location (UCSC) Chr 13: 98.68 – 98.75 Mb Chr 14: 121.7 – 121.74 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse PepT 1 is a proton-coupled peptide cotransporter in epithelial cells. Peptide transporter 1 (PepT 1) also known as solute ...
Therapeutic drug monitoring (TDM) is a branch of clinical chemistry and clinical pharmacology that specializes in the measurement of medication levels in blood.Its main focus is on drugs with a narrow therapeutic range, i.e. drugs that can easily be under- or overdosed. [1]
Hence, inhibition of the HIV protease is one of the most important approaches for the therapeutic intervention in HIV infection [2] and their development is regarded as major success of structure-based drug design. [3] They are highly effective against HIV [4] and have, since the 1990s, been a key component of anti-retroviral therapies for HIV ...
Drug reaction testing uses a genetic test to predict how a particular person will respond to various prescription and non-prescription medications. It checks for genes that code for specific liver enzymes which activate, deactivate, or are influenced by various drugs.
Beta-secretase 1, also known as beta-site amyloid precursor protein cleaving enzyme 1, beta-site APP cleaving enzyme 1 (BACE1), membrane-associated aspartic protease 2, memapsin-2, aspartyl protease 2, and ASP2, is an enzyme that in humans is encoded by the BACE1 gene. [5] Expression of BACE1 is observed mainly in neurons and oligodendrocytes. [6]
P-gp is a 170 kDa transmembrane glycoprotein, which includes 10–15 kDa of N-terminal glycosylation.The N-terminal half of the protein contains six transmembrane helixes, followed by a large cytoplasmic domain with an ATP-binding site, and then a second section with six transmembrane helixes and an ATP-binding domain that shows over 65% of amino acid similarity with the first half of the ...