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Within each developing radial unit, the process of neurogenesis gives rise to post-mitotic (non-dividing) cortical neurons, which begin the process of radial neuronal migration from the ventricular zone and adjacent subventricular zone to form the cortical plate in the classic 'inside-out' manner beginning with the deep cortical layers.
The ventricular and subventricular zones exist inferior to the intermediate zone and communicate with other zones through cell signalling. These zones additionally create neurons destined to migrate to other areas in the cortex. [1] [6] The marginal zone, along with the cortical zone, make up the 6 layers that form the cortex. This zone is the ...
In 1891 Santiago Ramón y Cajal described slender horizontal bipolar cells he had found in an histological preparation of the developing marginal zone of lagomorphs. [28] These cells were then considered by Gustaf Retzius as homologous to the ones he had found in the marginal zone of human fetuses around mid-gestation in 1893 and 1894. He ...
The marginal zone is the region at the interface between the non-lymphoid red pulp and the lymphoid white-pulp of the spleen. (Some sources consider it to be the part of red pulp which borders on the white pulp, while other sources consider it to be neither red pulp nor white pulp.) A marginal zone also exists in the lymphoid follicles of lymph ...
The subplate, also called the subplate zone, together with the marginal zone and the cortical plate, in the fetus represents the developmental anlage of the mammalian cerebral cortex. It was first described, as a separate transient fetal zone by Ivica Kostović and Mark E. Molliver in 1974.
The central‐marginal hypothesis, also sometimes called the "central-peripheral population hypothesis", posits that there is less genetic diversity and greater inter‐population genetic differentiation at the range margins, as compared to the range cores.
In humans the splenic marginal zone B cells have evidence of somatic hypermutation in their immunoglobulin genes, indicating that they have been generated through a germinal centre reaction to become memory cells. While naive MZ B cells produce low-affinity IgM antibodies, memory MZ B cells express high-affinity Ig molecules.
Extranodal marginal zone lymphomas (EMZLs) are a form of MZL [9] in which malignant marginal zone B-cells initially infiltrate MALT tissues of the stomach (50-70% of all EMZL) or, less frequently, the esophagus, small intestine, large intestine, rectum, conjunctiva of the eye, nasal passages, pharynx, lung bronchi, vulva, vagina, skin, breast, thymus gland, meninges (i.e. membranes) that ...