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Within each developing radial unit, the process of neurogenesis gives rise to post-mitotic (non-dividing) cortical neurons, which begin the process of radial neuronal migration from the ventricular zone and adjacent subventricular zone to form the cortical plate in the classic 'inside-out' manner beginning with the deep cortical layers.
The marginal zone is the region at the interface between the non-lymphoid red pulp and the lymphoid white-pulp of the spleen. (Some sources consider it to be the part of red pulp which borders on the white pulp, while other sources consider it to be neither red pulp nor white pulp.) A marginal zone also exists in the lymphoid follicles of lymph ...
The marginal zone, along with the cortical zone, make up the 6 layers that form the cortex. This zone is the predecessor for layer I of the cortex. Astrocytes form an outer limiting membrane to interact with the pia. In humans it has been found that the cells here also form a subpial layer. [1]
Extranodal marginal zone lymphomas (EMZLs) are a form of MZL [9] in which malignant marginal zone B-cells initially infiltrate MALT tissues of the stomach (50-70% of all EMZL) or, less frequently, the esophagus, small intestine, large intestine, rectum, conjunctiva of the eye, nasal passages, pharynx, lung bronchi, vulva, vagina, skin, breast, thymus gland, meninges (i.e. membranes) that ...
Causes and effects from a common cause. One famous example of the importance of this is the Duhem–Quine thesis, which demonstrates that it is impossible to test a hypothesis in isolation, because an empirical test of the hypothesis requires one or more background assumptions. One way to solve this issue is to employ contrastive explanations.
In humans the splenic marginal zone B cells have evidence of somatic hypermutation in their immunoglobulin genes, indicating that they have been generated through a germinal centre reaction to become memory cells. While naive MZ B cells produce low-affinity IgM antibodies, memory MZ B cells express high-affinity Ig molecules.
The central‐marginal hypothesis, also sometimes called the "central-peripheral population hypothesis", posits that there is less genetic diversity and greater inter‐population genetic differentiation at the range margins, as compared to the range cores.
During the midfetal period of fetal development the subplate zone is the largest zone in the developing telencephalon. It serves as a waiting compartment for growing cortical afferents ; its cells are involved in the establishment of pioneering cortical efferent projections and transient fetal circuitry, and apparently have a number of other ...