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A shigella infection can cause bloody diarrhea, fever and stomach pain, among other symptoms, making this an illness no one wants to have.
Insufficient data exist, [25] but it is estimated to have caused the death of 34,000 children under the age of five in 2013, and 40,000 deaths in people over five years of age. [16] Shigella also causes about 580,000 cases annually among travelers and military personnel from industrialized countries. [26]
The ACIP was established in March 1964 by the US Surgeon General to assist in the prevention and control of communicable diseases, [2] it recommends licensed new vaccines to be incorporated into the routine immunization schedule, recommends vaccine formulations, and reviews older vaccines to consider revising its recommendations.
For example, Shigella is a longstanding World Health Organization (WHO) target for vaccine development, and sharp declines in age-specific diarrhea/dysentery attack rates for this pathogen indicate that natural immunity does develop following exposure; thus, vaccination to prevent this disease should be feasible. The development of vaccines ...
Hence, Shigella cells may cause dysentery. In rare cases, young children may have seizures. Symptoms can take as long as a week to appear, but most often begin two to four days after ingestion. Symptoms usually last for several days, but can last for weeks. Shigella is implicated as one of the pathogenic causes of reactive arthritis worldwide. [21]
Since 1990, when the vaccine was introduced as a routine vaccination in children, rates of acute Hepatitis B has decreased in the United States by 82%. This vaccine is given as a series of shots, the first dose is given at birth, the second between 1 and 2 months, and the third, and possibly fourth, between 6 and 18 months.
The term is usually restricted to Shigella infections. [2] Shigellosis is caused by one of several types of Shigella bacteria. [3] Three species are associated with bacillary dysentery: Shigella sonnei, Shigella flexneri and Shigella dysenteriae. [4] A study in China indicated that Shigella flexneri 2a was the most common serotype. [5]
Shigella flexneri is a rod shaped, nonflagellar bacterium that relies on actin-based motility. It produces the protein actin in a swift and continuous fashion to propel itself forward within and between the host's cells. [4] This bacterium is gram-negative, non-spore forming Shigella from serogroup B. There are 6 serotypes within this serogroup.
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