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The function of the spinal dorsal horn is to process and integrate sensory information from the peripheral nervous system. It receives inputs from primary afferent fibers and modulatory systems, and it projects to higher brain centers and motor neurons .
Stimulation of the periaqueductal gray matter of the midbrain activates enkephalin-releasing neurons that project to the raphe nuclei in the brainstem. 5-HT released from the raphe nuclei descends to the dorsal horn of the spinal cord where it forms excitatory connections with the inhibitory interneurons located in Laminae II (aka the substantia gelatinosa).
Posterior horn of lateral ventricle in the brain, which passes forward, laterally and slightly downward, from the corpus callosum into the occipital lobe; Posterior horn of spinal cord, the dorsal (towards the back) grey matter section of the spinal cord that receives several types of sensory information from the body including light touch ...
Lamina V: Neck of the dorsal horn. Neurons within lamina V are mainly involved in processing sensory afferent stimuli from cutaneous, muscle and joint mechanical nociceptors as well as visceral nociceptors. This layer is home to wide dynamic range tract neurons, interneurons and propriospinal neurons.
In the neural tube cells are specified to either the rostral-caudal axis or ventral-dorsal axis. The axons of motor neurons begin to appear in the fourth week of development from the ventral region of the ventral-dorsal axis (the basal plate). [8] This homeodomain is known as the motor neural progenitor domain (pMN).
Glutamate released from the upper motor neurons triggers depolarization in the lower motor neurons in the anterior grey column, which in turn causes an action potential to propagate the length of the axon to the neuromuscular junction where acetylcholine is released to carry the signal across the synaptic cleft to the postsynaptic receptors of the muscle cell membrane, signaling the muscle to ...
Lateral ventricles and horns The lateral ventricles connected to the third ventricle by the interventricular foramina. Each lateral ventricle takes the form of an elongated curve, with an additional anterior-facing continuation emerging inferiorly from a point near the posterior end of the curve; the junction is known as the trigone of the lateral ventricle.
C fibers cause central sensitization of the dorsal horn in the spinal cord in response to their hyperactivity. [5] The mechanism underlying this phenomenon involves the release of glutamate by these pathologically sensitized C fibers. [5] The glutamate interacts with the postsynaptic NMDA receptors, which aids the sensitization of the dorsal ...