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The second episode of the TV series Seal Team (season 1) focuses on a chemical weapons lab in an abandoned hospital, producing VX gas. In the Netflix show Designated Survivor, agent Hannah Wells is killed by VX in season 3, episode 7. In the CBS show MacGyver, season 2 episode 9, a VX canister is the main plot point.
Toxin is a fictional character appearing in American comic books published by Marvel Comics.He has been depicted as a superhero and at times a supervillain.The character is the offspring of Carnage, the third major symbiote in the Marvel Universe, the ninth known to have appeared in the comics outside of the Planet of the Symbiotes storyline, and the first symbiote that Spider-Man considers an ...
Toxic shock syndrome toxin-1 (TSST-1) is a superantigen with a size of 22 kDa [1] produced by 5 to 25% of Staphylococcus aureus isolates. It causes toxic shock syndrome (TSS) by stimulating the release of large amounts of interleukin-1, interleukin-2 and tumor necrosis factor. In general, the toxin is not produced by bacteria growing in the ...
Charybdotoxin (ChTX) is a 37 amino acid neurotoxin from the venom of the scorpion Leiurus quinquestriatus hebraeus (deathstalker) that blocks calcium-activated potassium channels. [2] This blockade causes hyperexcitability of the nervous system. It is a close homologue of agitoxin and both toxins come from Leiurus quinquestriatus hebraeus.
The toxin is usually an AB toxin, a cytotoxic protein derived from a bacterial or plant protein, from which the natural binding domain has been removed so that the Fv directs the toxin to the antigen on the target cell. [1] Sometimes recombinant fusion proteins containing a toxin and a growth factor are also referred to as recombinant ...
As a powerful anticholinergic agent, BZ produces a syndrome of effects known as the anticholinergic toxidrome: these include both psychological and physiological effects, with the most incapacitating effect being a state of delirium characterized by cognitive dysfunction, hallucinations, and inability to perform basic tasks.
The toxin inhibits the activation of Nav channels by binding to the linker in the L3-4 loop (between the S3 and S4 segments) above the central cavity of VSD-II, which is known as site 4. [6] ProTx-II inhibits sodium currents by shifting the voltage-dependence of the channel activation to more positive potentials.
The RTX toxin superfamily is a group of cytolysins and cytotoxins produced by bacteria. [1] There are over 1000 known members with a variety of functions. [2] The RTX family is defined by two common features: characteristic repeats in the toxin protein sequences, and extracellular secretion by the type I secretion systems (T1SS).