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  2. Metformin - Wikipedia

    en.wikipedia.org/wiki/Metformin

    Metformin has acid dissociation constant values (pK a) of 2.8 and 11.5, so it exists very largely as the hydrophilic cationic species at physiological pH values. The metformin pK a values make it a stronger base than most other basic medications with less than 0.01% nonionized in blood.

  3. Topical gels - Wikipedia

    en.wikipedia.org/wiki/Topical_gels

    The drug can penetrate deeply into the skin [2] and be directly delivered to the target site, as the topical application allows it to avoid hepatic first pass metabolism. [1] [2] [8] [6] Difficulties in gastrointestinal absorption caused by pH, enzymatic activity and drug-food interactions can be minimized, while at the same time avoiding GI ...

  4. 6 Benefits of Taking Metformin (Besides Weight Loss) - AOL

    www.aol.com/6-benefits-taking-metformin-besides...

    2. Alleviates Hunger. Metformin improves how well your cells respond to insulin. This helps regulate your blood sugar levels and manage spikes in insulin that can trigger hunger and food cravings.

  5. Pioglitazone/metformin - Wikipedia

    en.wikipedia.org/wiki/Pioglitazone/metformin

    Pioglitazone/metformin is indicated as an adjunct to diet and exercise: [medical citation needed] To improve glycemic control in patients with type 2 diabetes, or; For patients who are already treated with a separate combination of pioglitazone and metformin, For patients whose diabetes is not adequately controlled with metformin alone, or

  6. Is There a "Best Time" to Take Metformin? - AOL

    www.aol.com/best-time-metformin-115700262.html

    Well, there’s no magic time, but you should take metformin at the same time each day and with food to avoid gastrointestinal side effects. If you’re taking extended-release metformin tablets ...

  7. Pharmacokinetics - Wikipedia

    en.wikipedia.org/wiki/Pharmacokinetics

    Therefore, if a drug has a bioavailability of 0.8 (or 80%) and it is administered in a dose of 100 mg, the equation will demonstrate the following: De = 0.8 × 100 mg = 80 mg That is the 100 mg administered represents a blood plasma concentration of 80 mg that has the capacity to have a pharmaceutical effect.

  8. Immobilized pH gradient - Wikipedia

    en.wikipedia.org/wiki/Immobilized_pH_gradient

    The immobilized pH gradient is obtained by the continuous change in the ratio of Immobilines. An Immobiline is a weak acid or base defined by its pK value. [ 2 ] Immobilized pH gradients (IPG) are made by mixing two kinds of acrylamide mixture, one with Immobiline having acidic buffering property and other with basic buffering property. [ 3 ]

  9. Acetic acid (medical use) - Wikipedia

    en.wikipedia.org/wiki/Acetic_acid_(medical_use)

    As a liquid it is used to flush the bladder in those who have a urinary catheter in an attempt to prevent infection or blockage. [3] As a gel it may be used to adjust the pH of the vagina. [4] It may also be applied to the cervix to help detect cervical cancer during screening. [5] Side effects may include burning at the site of application. [6]

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