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Metformin is one of many medications that can cause lactic acidosis. Symptoms of lactic acidosis include nausea, vomiting and weakness. Fortunately, the risk of lactic acidosis is a rare side ...
Lactic acidosis is commonly found in people who are unwell, such as those with severe heart and/or lung disease, a severe infection with sepsis, the systemic inflammatory response syndrome due to another cause, severe physical trauma, or severe depletion of body fluids. [3]
Metformin itself isn’t thought to cause hair loss, but type 2 diabetes and PCOS (polycystic ovary syndrome) — the conditions it’s prescribed to treat — can cause hair loss.
Given severely impaired kidney function, clearance of metformin and lactate is reduced, increasing levels of both, and possibly causing lactic acid buildup. Because metformin decreases liver uptake of lactate, any condition that may precipitate lactic acidosis is a contraindication.
The medication most commonly may cause stomach upset and symptoms such as diarrhea but in general is well tolerated and has a relatively low chance of causing hypoglycemia. [35] One rare (about 1% chance) but serious side affect of metformin is that it can cause lactic acidosis, usually in patients with poor kidney function. [35]
Phenformin (DBI) was used from 1960s through 1980s, but was withdrawn due to lactic acidosis risk. [11] Buformin also was withdrawn due to lactic acidosis risk. [12] Metformin is a first-line medication used for treatment of type 2 diabetes.
The expected result of the treatment tackles the deeper causes; which are dehydration, acidosis, and hyperglycemia, and initiates a reversal of the ketosis process. [9] While replacing fluid and electrolyte loss, insulin, and acid-placed balance are the aim of this treatment.
The most common causes of high anion gap metabolic acidosis are: ketoacidosis, lactic acidosis, kidney failure, and toxic ingestions. [3]Ketoacidosis can occur as a complication of diabetes mellitus (diabetic ketoacidosis), but can occur due to other disorders, such as chronic alcoholism and malnutrition.