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A retrospective analysis of wound cleanser clinical efficacy and cost-effectiveness focused on polyhexamethylene biguanide solution, Ringer's solution or saline in 112 venous leg ulcer patients. [31] The study group received the polyhexamethylene biguanide solution (n=59) and the control group received either Ringer's solution or saline (n=53).
Biguanide (/ b aɪ ˈ ɡ w ɒ n aɪ d /) is the organic compound with the formula HN(C(NH)NH 2) 2. It is a colorless solid that dissolves in water to give a highly basic solution. It is a colorless solid that dissolves in water to give a highly basic solution.
Polyhexanide (polyhexamethylene biguanide, PHMB) is a polymer used as a disinfectant and antiseptic. In dermatological use, [ 4 ] it is spelled polihexanide ( INN ) and sold under various brand names. [ 5 ]
Premedication is using medication before some other therapy (usually surgery or chemotherapy) to prepare for that forthcoming therapy.Typical examples include premedicating with a sedative or analgesic before surgery; using prophylactic (preventive) antibiotics before surgery; and using antiemetics or antihistamines before chemotherapy.
Structure of chlorhexidine, a bisbiguanide antiseptic.. Bisbiguanides are a class of chemically related compounds known for their bactericidal properties. Generally considered to be of the generic formula: R 1 R 2 N.C(:NR 6)NH.C(:NH)NH.CH 2 X--(CH 2) 3 NH.C(:NH)NH.C(:NR 7)NR 3 R 4 V. [1] These compounds include the antiseptics chlorhexidine and alexidine.
Polyaminopropyl biguanide (PAPB) is a polymer containing biguanide group connected with a three methylene (propyl) linker. The polymer is a propyl analogue of polyhexamethylene biguanide . The polymer display some antibacterial activity however much lower than PHMB.
Chlorhexidine [1] is a disinfectant and antiseptic with the molecular formula C 22 H 30 Cl 2 N 10, which is used for skin disinfection before surgery and to disinfect surgical instruments. [2] It is also used for cleaning wounds , preventing dental plaque , treating yeast infections of the mouth , and to keep urinary catheters from blocking. [ 3 ]
The pulmonary toxicity of PHMG was discovered due to an outbreak of lung diseases in South Korea, detected in children between 2006 and 2011, and in adults in the spring of 2011; the mortality rate in children was 58%, while among adults, 53% died or required lung transplantation. [4]