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Phenylbiguanide (PBG) is a 5-HT3 agonist used to study the role of 5-HT3 receptors in the central nervous system. [1] It has been found to trigger dopamine release in the nucleus accumbens of rats. [ 2 ]
The mechanism of action of biguanides is not fully understood, and many mechanisms have been proposed for metformin. [citation needed]Biguanides do not affect the output of insulin, unlike other hypoglycemic agents such as sulfonylureas and meglitinides.
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This page was last edited on 27 November 2021, at 21:10 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
It acts as a monoamine releaser with selectivity for serotonin and has a similar potency to MDMA. [1] [2] [5] [3] [6] In terms of monoamine release, (S)-βk-5-MAPB has shown a DAT Tooltip dopamine transporter /SERT Tooltip serotonin transporter ratio of 0.6 and a DAT/NET Tooltip norepinephrine transporter ratio of 2.7, while (R)-βk-5-MAPB has shown a DAT/SERT ratio of 18 and a DAT/NET ratio ...
It acts as a serotonin 5-HT 2A receptor agonist, serotonin 5-HT 2B receptor antagonist, and also interacts with other serotonin receptors, such as the serotonin 5-HT 1F receptor (agonist), 5-HT 2C receptor (very weak partial agonist or antagonist), and 5-HT 6 receptor (agonist).
This page was last edited on 7 September 2024, at 15:37 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
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