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For decades prior to their discovery, it was widely believed that PUD was caused by excess acid in the stomach. During this time, acid control was the primary method of treatment for PUD, to only partial success. Among other effects, it is now known that acid suppression alters the stomach milieu to make it less amenable to H. pylori infection.
Peptic ulcer disease is when the inner part of the stomach's gastric mucosa (lining of the stomach), the first part of the small intestine, or sometimes the lower esophagus, gets damaged. An ulcer in the stomach is called a gastric ulcer , while one in the first part of the intestines is a duodenal ulcer . [ 1 ]
Gastric ulcer in antrum of stomach with overlying clot. Pathology was consistent with gastric lymphoma. A number of medications increase the risk of bleeding including NSAIDs and SSRIs. SSRIs double the rate of upper gastrointestinal bleeding. [4] There are many causes for upper gastrointestinal hemorrhage.
“A peptic ulcer is a sore or a break in the tissue that lines your stomach or small intestine,” explains Dr. Leah DeCoste, MD, a gastroenterologist with Gastro Health in Acton, Massachusetts ...
The gastric folds (or gastric rugae) are coiled sections of tissue that exist in the mucosal and submucosal layers of the stomach. [1] They provide elasticity by allowing the stomach to expand when a bolus enters it. These folds stretch outward through the action of mechanoreceptors, which respond to the increase in pressure. [2]
In rare cases, bloating may occur in individuals who have milk intolerance (lactose intolerance), parasite infections such as giardia, food poisoning , celiac disease, severe peptic ulcer disease, bowel obstruction, or after certain types of abdominal surgery. [5] Heart failure and cirrhosis are also a common cause of distension. In both of ...
Forrest's classification is instrumental when stratifying patients with upper gastrointestinal hemorrhage into high and low risk categories for mortality.It is also a significant method of prediction of the risk of rebleeding and very often is used for evaluation of the endoscopic intervention modalities. [3]
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