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Cryoglobulinemia is a medical condition in which the blood contains large amounts of cryoglobulins (atypical proteins in the blood) that become insoluble at low temperatures. [ 1 ] Cryoglobulinemia is also one of three types in its own family.
Cryoglobulinemic vasculitis is a form of inflammation affecting the blood vessels caused by the deposition of abnormal proteins called cryoglobulins.These immunoglobulin proteins are soluble at normal body temperatures, but become insoluble below 37 °C (98.6 °F) and subsequently may aggregate within smaller blood vessels.
Cold sensitive antibodies (CSA) are antibodies sensitive to cold temperature. Some cold sensitive antibodies are pathological and can lead to blood disorder.These pathological cold sensitive antibodies include cold agglutinins, Donath–Landsteiner antibodies, and cryoglobulins which are the culprits of cold agglutinin disease, paroxysmal cold hemoglobinuria in the process of Donath ...
Cryoglobulinemia: Triad of Reactive arthritis: Urethritis, conjunctivitis and anterior uveitis, arthritis: Reactive arthritis: Saint's Triad: Gall stones, Diverticulosis, Hiatus hernia: Samter's triad (also known as Acetylsalicylic acid triad or Widal's triad [citation needed] or Francis' triad [citation needed] or Aspirin triad)
Many cases of cryoglobulinemia vasculitis are asymptomatic. [27] Hyperviscosity and/or thrombosis are the principal signs and symptoms of type I cryoglobulinemia . As a result, the conditions most frequently manifested as Raynaud's phenomenon , distal gangrene , ischemic ulcers, purpura , livedo reticularis , headache , retinal hemorrhages, and ...
Meltzer's triad indicates the condition cryoglobulinemia. Huntington's disease is a neurodegenerative disease that is characterized by a triad of motor, cognitive, and psychiatric signs and symptoms. [31] A large number of these groups that can be characteristic of a particular disease are known as a syndrome.
Cryofibrinogenemia is also often associated with the inflammatory vasculitis that accompanies mixed Cryoglobulinemia#Classification, i.e. cryoglobulinemic vasculitis, particularly but not exclusively in instances where hepatitis C virus is an underlining disease. [6]
Autoamputation is a feature of ainhum, cryoglobulinemia [2] and thromboangiitis obliterans. In 1881, Thornton made the case of autoamputation. [3] Autoamputation could be the result of severe cases of certain chronic wounds, such as frostbite.