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Effects of long-term benzodiazepine use may include disinhibition, impaired concentration and memory, depression, [19] [20] as well as sexual dysfunction. [6] [21] The long-term effects of benzodiazepines may differ from the adverse effects seen after acute administration of benzodiazepines. [22]
Lorazepam, sold under the brand name Ativan among others, is a benzodiazepine medication. [14] It is used to treat anxiety (including anxiety disorders ), trouble sleeping , severe agitation , active seizures including status epilepticus , alcohol withdrawal , and chemotherapy-induced nausea and vomiting . [ 14 ]
Benzodiazepines are one of the most highly prescribed classes of drugs, [7] and they are commonly used in self-poisoning. [8] [9] Over 10 years in the United Kingdom, 1512 fatal poisonings have been attributed to benzodiazepines with or without alcohol. [10] Temazepam was shown to be more toxic than the majority of benzodiazepines.
The mechanism underlying rapid response to benzodiazepines and zolpidem in catatonia is unknown. [6] The observation that zolpidem, a selective hypnosedative with little to no muscle relaxing properties, elicits a challenge response similar to benzodiazepines has called into question the hypothesis that lorazepam may reverse catatonia through myorelaxation.
“I’ve got Ativan here. It’s less addictive.” It had taken me months to get off Ativan, which I had done the year before, using Valium to taper down. For me it has gone: 1985 - 2009 Booze, and occasionally a little cocaine, speed or weed. 2009 - 2010 Baclofen, Ativan, lithium, Wellbutrin, Zoloft, and two or three others with chemical names
Drug Name Common Trade Names [a] Year Approved (Typical Oral Dosage Formulations (mg) Approx. Equivalent Oral Dose to 10 mg Diazepam [b] (mg) Peak Onset of Action
One concern with kratom, specifically, is the risk of it being contaminated with salmonella, as well as heavy metals — something the FDA warned consumers about in 2019. Kratom and wellness
One view is that many of the short-term effects continue into the long-term and may even worsen, and are not resolved after stopping benzodiazepine usage. Another view maintains that cognitive deficits in chronic benzodiazepine users occur only for a short period after the dose, or that the anxiety disorder is the cause of these deficits.