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Ciclosporin, also spelled cyclosporine and cyclosporin, is a calcineurin inhibitor, used as an immunosuppressant medication. It is taken orally or intravenously for rheumatoid arthritis , psoriasis , Crohn's disease , nephrotic syndrome , eczema , and in organ transplants to prevent rejection .
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Ciclosporin A also has anti-inflammatory, antifungal, and antiparasitic abilities. It has been recommended for autoimmune diseases as well as potential treatment for rheumatoid arthritis, type I diabetes, and HIV-1. [19] Despite its use in medicine, cyclosporine A exhibits significant nephrotoxicity, cardiotoxicity, and hepathotoxicity. [21]
Ciclosporin is a cyclic polypeptide that has been used widely as an orally-available immunosuppressant. [1] It was originally used to prevent transplant rejection of solid organs but has also found use as an orally administered agent to treat psoriasis, [2] rheumatoid arthritis, [3] dry eye [4] and other auto-immune related conditions.
Calcineurin is a heterodimer of a 61-kD calmodulin-binding catalytic subunit, calcineurin A and a 19-kD Ca 2+-binding regulatory subunit, calcineurin B.There are three isozymes of the catalytic subunit, each encoded by a separate gene (PPP3CA, PPP3CB, and PPP3CC) and two isoforms of the regulatory, also encoded by separate genes (PPP3R1, PPP3R2).
Sandimmune (cyclosporine injection, USP) [citation needed] Nelfinavir mesylate, HIV protease inhibitor [citation needed] Propofol, intravenous anaesthetic agent, originally solublized with Cremophor EL in trials; later approved with a lipid emulsion [citation needed] Diazepam injection; superseded by lipid emulsion alternative (Diazemuls ...
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Voclosporin, sold under the brand name Lupkynis, is a calcineurin inhibitor used as an immunosuppressant medication for the treatment of lupus nephritis. [2] [4] It is an analog of ciclosporin that has enhanced action against calcineurin and greater metabolic stability.
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related to: cyclosporine emu also known as cream- 109 S High St #100, Columbus, OH · Directions · (614) 224-4261
"The lowest prices on generic prescriptions." - The New York Times