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Selamectin, sold under the brand name Revolution, among others, is a topical parasiticide and anthelminthic used on dogs and cats. [2] It treats and prevents infections of heartworms , fleas , ear mites , sarcoptic mange (scabies), and certain types of ticks in dogs, and prevents heartworms, fleas, ear mites, hookworms , and roundworms in cats.
A comparison of 3 insecticides (selamectin, fipronil, imidacloprid) showed that selamectin reduced larval cat fleas ≥93.5% after 24 h at doses of ≥0.3 μg. In contrast, at 24 h neither fipronil nor imidacloprid reached 90% reduction, even at the highest doses tested (0.5 μg for fipronil and 5.0 μg for imidacloprid).
Sarolaner is also an ingredient in feline combination antiparasitic Revolution Plus (or Stronghold Plus [12]), which contains sarolaner and selamectin and is used for prevention of sarcoptic mange, feline hookworms, feline roundworms, ear mites, and heartworms, as well as treating and preventing fleas and ticks.
In pharmacology and medicine, dosage refers to the prescribed regimen for administering a medication or substance, encompassing the amount, frequency, and duration of use. [1] It is distinct from dose , which denotes a single, specific quantity of a drug or substance given at one time. [ 2 ]
Milbemycins have a similar mechanism of action, but a longer half-life than the avermectins. They open glutamate-sensitive chloride channels in neurons and myocytes of invertebrates, leading to hyperpolarisation of these cells and blocking of signal transfer. [2] They are in IRAC class 6. [3] Milbemycin is effective against some avermectin ...
A hotel worker accused of supplying drugs to Liam Payne before the One Direction singer’s death in Buenos Aires on Oct. 16., 2024 has reportedly turned himself in to the police.. Ezequiel David ...
(The Center Square) – A new Republican oversight report accuses former Congresswoman Liz Cheney of colluding with witnesses in the Jan. 6 Select Committee investigation that she oversaw. The ...
Milbemycin oxime is active against a broad spectrum of nematodes.Its miticide spectrum includes Sarcoptes and Demodex.The drug is FDA-approved for prevention of heartworm in dogs and cats, [4] although it is less potent against heartworms than ivermectin.