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  2. Deletion mapping - Wikipedia

    en.wikipedia.org/wiki/Deletion_mapping

    In genetics and especially genetic engineering, deletion mapping is a technique used to find out the mutation sites within a gene. The principle of deletion mapping involves crossing a strain which has a point mutation in a gene, with multiple strains who each carry a deletion in a different region of the same gene.

  3. Clastogen - Wikipedia

    en.wikipedia.org/wiki/Clastogen

    Aneugens induce mis-segregation of chromosomes into daughter cells while clastogens break the DNA and chromosome. A clastogen is a mutagenic agent that disturbs normal DNA related processes or directly causes DNA strand breakages, thus causing the deletion , insertion , or rearrangement of entire chromosome sections. [ 1 ]

  4. Deletion (genetics) - Wikipedia

    en.wikipedia.org/wiki/Deletion_(genetics)

    In genetics, a deletion (also called gene deletion, deficiency, or deletion mutation) (sign: Δ) is a mutation (a genetic aberration) in which a part of a chromosome or a sequence of DNA is left out during DNA replication.

  5. Mutagenesis - Wikipedia

    en.wikipedia.org/wiki/Mutagenesis

    In the laboratory, mutagenesis is a technique by which DNA mutations are deliberately engineered to produce mutant genes, proteins, or strains of organisms. Various constituents of a gene, such as its control elements and its gene product, may be mutated so that the function of a gene or protein can be examined in detail.

  6. Pseudodominance - Wikipedia

    en.wikipedia.org/wiki/Pseudodominance

    The pattern of inheritance in which a single recessive allele is inherited but is still expressed is known as pseudodominance. This mainly occurs with sex-linked genes (i.e., those on the sex chromosomes). The homogametic sex (females in humans) receive two of each sex chromosome and therefore need to be homozygous to show a recessive trait.

  7. Sister chromatids - Wikipedia

    en.wikipedia.org/wiki/Sister_chromatids

    Sister chromatids are by and large identical (since they carry the same alleles, also called variants or versions, of genes) because they derive from one original chromosome. An exception is towards the end of meiosis, after crossing over has occurred, because sections of each sister chromatid may have been exchanged with corresponding sections ...

  8. Loss of heterozygosity - Wikipedia

    en.wikipedia.org/wiki/Loss_of_heterozygosity

    The remaining copy of the tumor suppressor gene can be inactivated by a point mutation or via other mechanisms, resulting in a loss of heterozygosity event, and leaving no tumor suppressor gene to protect the body. Loss of heterozygosity does not imply a homozygous state (which would require the presence of two identical alleles in the cell).

  9. Muller's morphs - Wikipedia

    en.wikipedia.org/wiki/Muller's_morphs

    After Muller's classification of gene mutation, an isomorph was described as a silent point mutant with identical gene expression as the original allele. [4] [5] m/Df = m/Dp Therefore, with respect to the relationship between the original and mutated genes, one cannot talk about the effects of dominance and/or recessiveness. [4] [5] [6]