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Glycated hemoglobin (Hb A1c) < 50 years: 3.6 [5] 5.0 [5] % of Hb > 50 years: 3.9 [5] 5.3 [5] Haptoglobin < 50 years: 0.35 [5] 1.9 [5] g/L > 50 years: 0.47 [5] 2.1 [5 ...
Diabetic ketoacidosis occurs in 4.6–8.0 per 1000 people with diabetes annually. [30] Rates among those with type 1 diabetes are higher with about 4% in the United Kingdom developing DKA a year while in Malaysia the condition affects about 25% a year.
Type 2 diabetes makes up about 90% of cases of diabetes, with the other 10% due primarily to type 1 diabetes and gestational diabetes. [1] In type 1 diabetes, there is a lower total level of insulin to control blood glucose, due to an autoimmune-induced loss of insulin-producing beta cells in the pancreas.
People who are affected with diabetes are referred to as diabetics. Many diabetics require an exogenous source of insulin to keep their blood sugar levels within a safe target range. [22] [23] [24] In 1916, Nicolae C. Paulescu (1869–1931) succeeded in developing an aqueous pancreatic extract that normalized a diabetic dog.
The basic underlying cause may be the insulin resistance that precedes type 2 diabetes, which is a diminished capacity for insulin response in some tissues (e.g., muscle, fat). It is common for morbidities such as essential hypertension, obesity, type 2 diabetes, and cardiovascular disease (CVD) to develop. [97]
Diabetic retinopathy: is one of the manifestation microvascular complications of diabetes, which is characterized by blindness or reduced acuity. That is, diabetic retinopathy describes the retinal and vitreous hemorrhages or retinal capillary blockage caused by the increase of A1C, [68] which a measurement of blood glucose or sugar level. [69]
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