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The disorder has been named after Leo Ritter von Zombusch, who first described two cases of a brother and a sister in 1910. [7] The patients experienced patterns of redness and pustule formation over several years, often associated with use of topical medications. [2]
Spesolimab, sold under the brand name Spevigo, is a monoclonal antibody used for the treatment of generalized pustular psoriasis (GPP). [4] It is an interleukin-36 receptor (IL-36R) antagonist. [ 4 ] [ 6 ] It is given via injection into a vein.
Generalized pustular psoriasis (GPP) is a rare type of psoriasis that can present in a variety of forms. [1] Unlike the most general and common forms of psoriasis, GPP usually covers the entire body and with pus-filled blisters rather than plaques. GPP can present at any age, but is rarer in young children.
Pustular psoriasis can be localized, commonly to the hands and feet (palmoplantar pustulosis), or generalized with widespread patches occurring randomly on any part of the body. Acrodermatitis continua is a form of localized psoriasis limited to the fingers and toes that may spread to the hands and feet. [ 4 ]
Pustulosis palmaris et plantaris is a chronic recurrent pustular dermatosis (that is, a pustulosis or pustular psoriasis) localized on the palms and soles only, characterized histologically by intraepidermal pustules filled with neutrophils. [2]: 411, 628 [3]: 204 It can occur as part of the SAPHO syndrome. [4]
Psoriatic erythroderma can be congenital or secondary to an environmental trigger. [12] [13] [14] Environmental triggers that have been documented include sunburn, skin trauma, psychological stress, systemic illness, alcoholism, drug exposure, chemical exposure (e.g., topical tar, computed tomography contrast material), and the sudden cessation of medication.
Acute generalized exanthematous pustulosis (AGEP; also known as pustular drug eruption and toxic pustuloderma) is a rare skin reaction that in 90% of cases is related to medication. AGEP is characterized by sudden skin eruptions that appear on average five days after a medication is started.
Obesity and certain forms of psoriasis are thought to increase the risk. [3] Psoriatic arthritis affects up to 30% of people with psoriasis and occurs in both children and adults. [3] Some people with PsA never get psoriasis. [4] The condition is less common in people of Asian or African descent and affects men and women equally. [3]
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