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Studies on localized prostate cancer showed that, after treatment, progression-free survival rates were high for low- and intermediate- risk patients with recurrent prostate cancer. [2] The InsighTec ExAblate 2000 was the first MRgFUS system to obtain FDA market approval, [3] US patent 5,247,935.
For men over 64 with prostate cancer limited to the pelvis, using fewer, larger doses of radiation (hypofractionation) results in similar overall survival rates. [28] The risk of dying from prostate cancer or having acute bladder side effects may be similar to that of longer radiation treatment. [28]
The VIOLETTE trial assesses the efficacy of focal ablation of prostate cancer using a microwave needle guided by 3D image fusion into the index lesion. The last patient of a total of 76 was successfully enrolled on September 5 th , 2024, at the Clinique Saint-Augustin in Bordeaux - FRANCE.
Focal ablation using IRE for PCa in the distal apex appears safe and feasible. The concept of treating prostate cancer with IRE was first proposed by Gary Onik and Boris Rubinsky in 2007. [ 89 ] Prostate carcinomas are frequently located near sensitive structures which might be permanently damaged by thermal treatments or radiation therapy.
Transurethral needle ablation can be used to treat benign prostatic hyperplasia (BPH). [ 4 ] Some clinical studies have reported that TUNA is safe and effective, improving the urine flow with minimal side effects when compared with other procedures, such as transurethral resection of the prostate (TURP) and open prostatectomy .
Pulsed field ablation (PFA) is a non-thermal (not using extreme heat or cold) method of biological ablation (removal of structure or functionality) utilizing high-amplitude pulsed (microsecond duration) electric fields to create irreversible electroporation in tissues. [1] [2] It is used most widely to treat tumors or cardiac arrhythmias. [3]
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