Search results
Results from the WOW.Com Content Network
The haloalkanes (also known as halogenoalkanes or alkyl halides) are alkanes containing one or more halogen substituents. [1] They are a subset of the general class of halocarbons , although the distinction is not often made.
With secondary amines and not primary amines the Zincke reaction takes on a different shape forming so-called Zincke aldehydes in which the pyridine ring is ring-opened with the terminal iminium group hydrolyzed to an aldehyde: [4] Zincke aldehydes. This variation has been applied in the synthesis of novel indoles: [11] Zincke aldehydes Kearney ...
The Gabriel synthesis is a chemical reaction that transforms primary alkyl halides into primary amines.Traditionally, the reaction uses potassium phthalimide. [1] [2] [3] The reaction is named after the German chemist Siegmund Gabriel.
The vast majority of these procedures utilize the commercially available salt N,O-dimethylhydroxylamine hydrochloride [MeO(Me)NH•HCl], which is typically easier to handle than the free amine. [6] Treatment of an ester or lactone with AlMe 3 or AlMe 2 Cl affords the corresponding Weinreb amide in good yields. Alternatively, non-nucleophilic ...
The mechanism below begins with an O-acylated hydroxamic acid derivative that is treated with base to form an isocyanate that generates an amine and CO 2 gas in the presence of H 2 O. The hydroxamic acid derivative is first converted to its conjugate base by abstraction of a hydrogen by a base.
In organic chemistry, hydroamination is the addition of an N−H bond of an amine across a carbon-carbon multiple bond of an alkene, alkyne, diene, or allene. [1] In the ideal case, hydroamination is atom economical and green. [2] Amines are common in fine-chemical, pharmaceutical, and agricultural industries.
2-Aminoalcohols are an important class of organic compounds that are often generated by the reaction of amines with epoxides: C 2 H 4 O + R−NH 2 → RNHC 2 H 4 OH. Simple alkanolamines are used as solvents, synthetic intermediates, and high-boiling bases. [2] Hydrogenation or hydride reduction of amino acids gives the corresponding 2 ...
The Mannich reaction starts with the nucleophilic addition of an amine to a carbonyl group followed by dehydration to the Schiff base. The Schiff base is an electrophile which reacts in a second step in an electrophilic addition with an enol formed from a carbonyl compound containing an acidic alpha-proton.