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Aciclovir has a high distribution rate; protein binding is reported to range from 9 to 33%. [49] The elimination half-life (t 1/2) of aciclovir depends according to age group; neonates have a t 1/2 of 4 hours, children 1–12 years have a t 1/2 of 2–3 hours whereas adults have a t 1/2 of 3 hours. [3]
In 1999, the FDA approved oseltamivir phosphate for the treatment of influenza in adults [68] based on two double-blind, randomized, placebo-controlled clinical trials. [69] In June 2002, the European Medicines Agency (EMA) approved oseltamivir phosphate for prophylaxis and treatment of influenza. In 2003, a pooled analysis of ten randomised ...
The fifth version in 1957 saw its name change to The British National Formulary. [ 4 ] [ 5 ] A new-look version, under the auspices of Owen Wade , was released in 1981. [ 2 ] [ 6 ] A study in Northern Ireland, looking at prescribing in 1965, reported that the BNF was likely able to serve the requirements of prescribers in general practice ...
Several antiviral drugs are effective for treating herpes, including aciclovir (acyclovir), valaciclovir, famciclovir, and penciclovir. Aciclovir was the first discovered and is now available in generic. [65] Valaciclovir is also available as a generic [66] and is slightly more effective than aciclovir for reducing lesion healing time. [67]
Brivudine is used for the treatment of herpes zoster in adult patients. It is taken orally once daily, in contrast to aciclovir, valaciclovir and other antivirals. [1] A study has found that it is more effective than aciclovir, but this has been disputed because of a possible conflict of interest on part of the study authors.
Infection in otherwise healthy adults tends to be more severe. [66] Treatment with antiviral drugs (e.g. aciclovir or valaciclovir) is generally advised, as long as it is started within 24–48 hours from rash onset. [63] Remedies to ease the symptoms of chickenpox in adults are generally the same as those used for children.
As of 2016, darunavir is an OARAC recommended treatment option for treatment-naïve and treatment-experienced adults and adolescents. [7] Several ongoing phase III trials are showing a high efficiency for the darunavir/ritonavir combination being superior to the lopinavir/ritonavir combination for first-line therapy. [ 8 ]
Drug nomenclature is the systematic naming of drugs, especially pharmaceutical drugs.In the majority of circumstances, drugs have 3 types of names: chemical names, the most important of which is the IUPAC name; generic or nonproprietary names, the most important of which are international nonproprietary names (INNs); and trade names, which are brand names. [1]
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