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Heck-type cross coupling of phenylboronic acid and alkenes and alkynes has been demonstrated. [9] Aryl azides and nitroaromatics can also be generated from phenylboronic acid. [4] Phenylboronic acid can also be regioselectively halodeboronated using aqueous bromine, chlorine, or iodine: [10] PhB(OH) 2 + Br 2 + H 2 O → PhBr + B(OH) 3 + HBr
4-Formylphenyl boronic acid crystallizes in colorless needles [2] or is obtained as an odorless, whitish powder, which dissolves little in cold but better in hot water. The compound is quite stable [4] and readily forms dimers and cyclic trimeric anhydrides, which complicate purification and tend to protodeboronize, a secondary reaction that occurs frequently in the Suzuki coupling, with ...
4-Methylphenethylamine (4MPEA), also known as para-methylphenethylamine, is an organic compound with the chemical formula of C 9 H 13 N.4MPEA is a human trace amine associated receptor 1 (TAAR1) agonist, [2] a property which it shares with its monomethylated phenethylamine isomers, such as amphetamine (α-methylphenethylamine), β-methylphenethylamine, and N-methylphenethylamine (a trace amine).
4-Methylphenylisobutylamine (4-MAB), also known as 4-methyl-α-ethylphenethylamine, is a stimulant drug of the phenethylamine, amphetamine, and phenylisobutylamine families. [ 1 ] See also
4-Nonylphenylboronic acid is a potent and selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), with an IC 50 of 9.1nM, and 870x selectivity for FAAH over the related enzyme MAGL, which it inhibits with an IC 50 of 7900nM. [1]
4-Phenylphenol can be obtained from the Suzuki coupling of phenylboronic acid with 4-iodophenol in the presence of 10% palladium on carbon and potassium carbonate. [ 1 ] [ 2 ] Properties
1-Boc-4-AP (tert-butyl 4-(phenylamino)piperidine-1-carboxylate) is a compound used as an intermediate in the manufacture of fentanyl, as well as various related derivatives such as butyrylfentanyl, furanylfentanyl, benzylfentanyl and homofentanyl, among others.
4-(4-Methylphenyl)-4-oxobutanoic acid can be prepared by a Friedel–Crafts reaction between toluene and succinic anhydride catalyzed by a Lewis acid such as aluminium chloride. [ 2 ] References