Search results
Results from the WOW.Com Content Network
Piperazine is freely soluble in water and ethylene glycol, but insoluble in diethyl ether. It is a weak base with two pK b of 5.35 and 9.73 at 25 °C.; the pH of a 10% aqueous solution of piperazine is 10.8–11.8. Piperazine readily absorbs water and carbon dioxide from the air.
N-Methylpiperazine is a common building block used in organic synthesis. [2] For example, N-methylpiperazine is used in the manufacture of various pharmaceutical drugs including cyclizine, [3] meclizine, and sildenafil. The lithium salt, lithium N-methylpiperazide, is used as a reagent in organic synthesis for protection of aryl aldehydes. [4]
For example, the direct 2,5-DKP ring formation via such an activated leaving group using the stable, easily accessible and versatile convertible isonitrile 1-isocyano-2-(2,2-dimethoxyethyl)-benzene 4 gave a one-pot synthesis of N-substituted 2,5-diketopiperazine's 7. [11] One-pot synthesis of N-substituted 2,5-DKPs via indolamide
Aminoethylpiperazine (AEP) is a derivative of piperazine. This ethyleneamine contains three nitrogen atoms; one primary, one secondary and one tertiary. It is a corrosive organic liquid and can cause second or third degree burns. Aminoethylpiperazine can also cause pulmonary edema as a result of inhalation. It is REACH and TSCA registered. [1]
It is both a precursor in the synthesis of aripiprazole and one of its metabolites. [1] [2] It is unclear whether 2,3-DCPP is pharmacologically active as a serotonin receptor agonist similar to its close analogue 3-chlorophenylpiperazine (mCPP), though it has been shown to act as a partial agonist of the dopamine D 2 and D 3 receptors. [3]
The end product of the catalytic hydrogenation of nitrilotriacetonitrile is therefore 1-(2-aminoethyl)piperazine. Synthesis of aminoethylpiperazine by hydrogenation of NTAN. If the catalytic hydrogenation of NTAN is carried out with e. g. Raney nickel in the presence of a large excess of ammonia, it gives tris(2-aminoethyl)amine. [9]
1-(2-Pyrimidinyl)piperazine (1-PP, 1-PmP) is a chemical compound and piperazine derivative. It is known to act as an antagonist of the α 2 -adrenergic receptor (K i = 7.3–40 nM) [ 1 ] and, to a much lesser extent, as a partial agonist of the 5-HT 1A receptor (K i = 414 nM; E max = 54%).
1-(2-Pyridinyl)piperazine is a chemical compound and piperazine derivative. Some derivatives of this substance are known to act as potent and selective α 2-adrenergic receptor antagonists, such as 1-(3-fluoro-2-pyridinyl)piperazine. [1] A few pyridinylpiperazine derivatives are drugs, including: Azaperone — antipsychotic; Atevirdine ...