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Transforming growth factor beta-3 is a protein that in humans is encoded by the TGFB3 gene. [ 5 ] [ 6 ] It is a type of protein, known as a cytokine , which is involved in cell differentiation , embryogenesis and development .
Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three [1] different mammalian isoforms (TGF-β 1 to 3, HGNC symbols TGFB1, TGFB2, TGFB3) and many other signaling proteins. TGFB proteins are produced by all white blood cell lineages.
[3] [4] Isoforms of transforming growth factor-beta (TGF-β1) are also thought to be involved in the pathogenesis of pre-eclampsia. [5] They belong to the transforming growth factor beta family . TGFβ receptors are single pass serine/threonine kinase receptors .
The TGF beta superfamily of ligands includes: bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs), anti-Müllerian hormone (AMH), Activin, Nodal and TGFβs. [3] Signaling begins with the binding of a TGF beta superfamily ligand to a TGF beta type II receptor.
Transforming growth factor beta (TGF-β) is a potent cell regulatory polypeptide homodimer of 25kD. [1] It is a multifunctional signaling molecule with more than 40 related family members. TGF-β plays a role in a wide array of cellular processes including early embryonic development, cell growth, differentiation, motility, and apoptosis. [2]
Transforming growth factor-beta (TGF-beta) [6] is a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. TGF-beta-1 is a peptide of 112 amino acid residues derived by proteolytic cleavage from the C-terminal of a precursor protein.
Betaglycan also known as Transforming growth factor beta receptor III (TGFBR3), is a cell-surface chondroitin sulfate / heparan sulfate proteoglycan >300 kDa in molecular weight. Betaglycan binds to various members of the TGF-beta superfamily of ligands via its core protein, and bFGF via its heparan sulfate chains.
T helper 3 cells (T h 3) are a subset of T lymphocytes with immunoregulary and immunosuppressive functions, that can be induced by administration of foreign oral antigen. [1] T h 3 cells act mainly through the secretion of anti-inflammatory cytokine transforming growth factor beta ().
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