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Raloxifene is a selective estrogen receptor modulator (SERM) and therefore a mixed agonist–antagonist of the estrogen receptor (ER). [6] It has estrogenic effects in bone and antiestrogenic effects in the breasts and uterus. [6] Raloxifene was approved for medical use in the United States in 1997. [6] It is available as a generic medication.
Raloxifene belongs to the second-generation benzothiophene SERM drugs. It has a high affinity for the ER with potent antiestrogenic activity and tissue-specific effects distinct from estradiol. [19] Raloxifene is an ER agonist in bone and the cardiovascular system, but in breast tissue and the endometrium it acts as an ER antagonist.
One of the largest breast cancer prevention studies ever, [2] it included 22,000 women in 400 medical centers in the United States and Canada. [3] [4] [5]The study concluded that raloxifene caused fewer side-effects and less endometrial cancer than tamoxifen.
Hormone replacement therapy (HRT), also known as menopausal hormone therapy or postmenopausal hormone therapy, is a form of hormone therapy used to treat symptoms associated with female menopause. [ 1 ] [ 2 ] Effects of menopause can include symptoms such as hot flashes , accelerated skin aging, vaginal dryness , decreased muscle mass , and ...
A litter of two-week old puppies was crammed into a bucket and abandoned alongside a road in Union County, New Jersey on Thursday, police said. The nine puppies were found...
Raloxifene chemical structure Raloxifene is a known chemical compound used to treat osteoporosis . As a result of drug repositioning experiments, the E4C project identified raloxifene as a possible candidate to treat early-stage COVID-19 patients, [ 6 ] [ 5 ] aiming to prevent clinical progression. [ 25 ]
The trolls can keep throwing stones, but Prince Harry and Duchess Meghan are not on the rocks.. The Duke of Sussex addressed speculation about his relationship with wife Duchess Meghan during an ...
A Great White Shark swimming here, was spotted in waters where a shark is suspected of attacking a surfer on Granites Beach in South Australia on Jan. 2, 2025, police said.