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Fenbendazole is metabolized in the liver to oxfendazole, which is anthelmintic too; oxfendazole partially gets reduced back to fenbendazole in the liver and rumen. [10] [11] Also, fenbendazole itself is an active metabolite of another anthelmintic drug, febantel. [12]
Praziquantel has a serum half-life of 0.8 to 1.5 hours in adults with normal renal and liver function. Metabolites have a half-life of 4 to 5 hours. In patients with significantly impaired liver function (Child-Pugh score B and C), the serum half-life is increased to 3 to 8 hours. Praziquantel and its metabolites are mainly excreted renally ...
Albendazole is a broad-spectrum antihelmintic and antiprotozoal agent of the benzimidazole type. [3] It is used for the treatment of a variety of intestinal parasite infections, including ascariasis, pinworm infection, hookworm infection, trichuriasis, strongyloidiasis, taeniasis, clonorchiasis, opisthorchiasis, cutaneous larva migrans, giardiasis, and gnathostomiasis, among other diseases.
A lower dose should be used in people with liver disease. [2] While it does not appear to be harmful during pregnancy, it has not been studied for this use. [3] It is unclear if it is safe for use during breastfeeding. [2] It is in the antihelmintic family of medications. [4] It works by paralyzing worms. [4] Pyrantel was initially described in ...
Anthelmintic effect of papain on Heligmosomoides bakeri. Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host.
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A recent study on ascarids in Europe has discovered that P. univalens have started becoming resistant to a standard antihelmintic medication, pyrantel, whereas fenbendazole is still proven to be effective at removing the worms. [2] Other medications frequently used include ivermectin and moxidectin. The use of such medications can cause issues ...
The liver hairworm Capillaria hepatica is found primarily in rodents and lagomorphs; infections of dogs are rare. Infection occurs by eating the liver of a rodent. Clinically, symptoms such as abdominal discomfort and hepatomegalia occur as the larvae migrate through the liver and lay eggs. A definite diagnosis can only be made by liver biopsy ...
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