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In June 2023, the US FDA approved a low-dose regimen of colchicine (brand name Lodoco) to reduce the risk of further disorders in adults with existing cardiovascular diseases. [ 31 ] [ 32 ] As an anti-inflammatory drug, Lodoco in a dose of 0.5 mg per day reduced the rate of cardiovascular events by 31% in people with established atherosclerosis ...
Colistin was discovered in 1947 and colistimethate sodium was approved for medical use in the United States in 1970. [9] [8] It is on the World Health Organization's List of Essential Medicines. [14] The World Health Organization classifies colistin as critically important for human medicine. [15] It is available as a generic medication. [16]
The AUC is estimated to be 7693 ng/mL and the Cmax is estimated at 955 ng/mL. [11] The volume of distribution is approximately 2,154 L and distributes within the red blood cells. The distribution between the plasma and whole blood is affected by temperature and concentration. [11] The protein binding of voclosporin is 97%.
Attention deficit hyperactivity disorder management options are evidence-based practices with established treatment efficacy for ADHD.Approaches that have been evaluated in the management of ADHD symptoms include FDA-approved pharmacologic treatment and other pharmaceutical agents, psychological or behavioral approaches, combined pharmacological and behavioral approaches, cognitive training ...
Ethinylestradiol and norethisterone acetate (FemHRT) – 25 μg / 0.5 mg; Estradiol/progesterone (TX-001HR), a combination of estradiol and progesterone in oil-filled capsules, is currently pending approval. [45] Estradiol and norgestimate (Prefest; 1 mg / 90 μg) was previously available in the U.S. but was discontinued.
Additionally, in 2016, the FDA filed "Withdrawal of Approval of Indications Related to the Coadministration With Statins in Applications for Niacin Extended-Release Tablets and Fenofibric Acid Delayed Release Capsules" noting "the Agency has concluded that the totality of the scientific evidence no longer supports the conclusion that a drug ...
Maralixibat chloride, sold under the brand name Livmarli, is a medication used to treat cholestatic pruritus in people with Alagille syndrome. [5] [6] Maralixibat chloride is an ileal bile acid transporter (IBAT) inhibitor.
Levomilnacipran (brand name Fetzima) is an antidepressant which was approved in the United States in 2013 for the treatment of major depressive disorder (MDD) in adults. [5] It is the levorotatory enantiomer of milnacipran , and has similar effects and pharmacology , acting as a serotonin–norepinephrine reuptake inhibitor (SNRI).