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Crohn's disease is believed to be caused by a dysregulated immune response to gut bacteria, though the exact mechanism is unknown. This is evidenced by the disease's links to genes involved in bacteria defense and its occurrence in the ileum and colon, the most bacteria-dense segments of the intestine. [23]
In Crohn's disease, surgery involves removing the worst inflamed segments of the intestine and connecting the healthy regions, but unfortunately, it does not cure Crohn's or eliminate the disease. At some point after the first surgery, Crohn's disease can recur in the healthy parts of the intestine, usually at the resection site. [76] (For ...
As of 2019, about 4.9 million people globally were living with an inflammatory bowel disease (IBD) such as Crohn’s disease. Scientists are still unclear as to the exact cause of Crohn’s ...
Burrill Bernard Crohn (June 13, 1884 – July 29, 1983) [1] was an American gastroenterologist who made the first major advance to identify Crohn's disease, which now bears his name. [2] Although the description of Crohn's disease is by far his most famous accomplishment, Crohn had a long career both as a clinician and as a researcher who ...
Parasitic worms influence what kinds of T helper cells are activated. In the past, helminths were thought to simply suppress T-helper Type 1 (Th1) cells while inducing T-helper Type 2 (Th2) cells. [9] Rook points out that this hypothesis would only explain the regulatory effects of parasitic worms on autoimmune diseases caused by Th1 cells. [10]
Inflammatory bowel disease is a condition of unknown aetiology, classified as either Crohn's disease or ulcerative colitis, that can affect the intestines and other parts of the gastrointestinal tract. Other causes of illness include intestinal pseudoobstruction, and necrotizing enterocolitis. [5]: 850–862, 895–903
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