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Demineralized bone matrix (DBM) is allograft bone that has had the inorganic mineral removed, leaving behind the organic "collagen" matrix. It was first discovered by Marshall Urist in 1965 that the removal of the bone mineral exposes more biologically active bone morphogenetic proteins . [ 1 ]
On the basis of the above work, it seemed likely that morphogens were present in the bone matrix. Using a battery of bioassays for bone formation, a systematic study was undertaken to isolate and purify putative bone morphogenetic proteins. A major stumbling block to purification was the insolubility of demineralized bone matrix.
Demineralized freeze dried bone allograft, referred to as DFDBA, is a bone graft material known for its de novo bone formation properties. [1] It is used extensively in bone grafting of alveolar bone in oral and periodontal surgery.
Bone tissue is a dynamic system with active metabolism. [24] Bone tissue remodelling or bone remodeling is a successive chain of old bone matrix removal and its replacement with a new one. [25] These processes make a child’s skeleton grow and extend, while childhood is characterized by bone tissue growth rather than its resorption.
In biology, matrix (pl.: matrices) is the material (or tissue) in between a eukaryotic organism's cells. The structure of connective tissues is an extracellular matrix. Fingernails and toenails grow from matrices. It is found in various connective tissues. It serves as a jelly-like structure instead of cytoplasm in connective tissue.
Burnt to a crisp by lava from Mount Vesuvius in A.D. 79, the reams of rolled-up papyrus were discovered in a mansion in Herculaneum — an ancient Roman town near Pompeii — in the mid-18th century.
Bone mineral is formed predominantly from carbonated hydroxyapatite [1] [2] with lower crystallinity. [1] [3] Bone mineral is formed from globular and plate structures [3] [4] distributed among the collagen fibrils of bone and forming yet a larger structure. The bone salt and collagen fibers together constitute the extracellular matrix of bone
The beach at the Herculaneum archaeological park is thought to be the site where more than 300 men tried in vain to save themselves while awaiting rescue by Pliny the Elder.