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Thomas Addison (April 1795 – 29 June 1860) was an English physician and medical researcher. He is traditionally regarded as one of the "great men" of Guy's Hospital in London. Thomas Addison began his career at Guy's Hospital in 1817, eventually becoming a full physician in 1837. He was a noted and respected lecturer and diagnostician.
A case of anemia with a first recognition of associated atrophic gastritis a feature of pernicious anemia, was first described in 1824 by James Combe. This was fully investigated in 1849, by British physician Thomas Addison, from which it acquired the common name of Addison's anemia.
The disease referred to a chronic progressive adrenal insufficiency, and was described in 1855 by the Englishman Thomas Addison, who gave it his name, Addison's disease. [9] The cardinal signs included asthenia , low blood pressure , anorexia (with weight loss) and melanoderma, with hyperpigmentation of the skin at friction points and of the ...
Between 1849 and 1887, Thomas Addison described a case of pernicious anemia, William Osler and William Gardner first described a case of neuropathy, Hayem described large red cells in the peripheral blood in this condition, which he called "giant blood corpuscles" (now called macrocytes), Paul Ehrlich identified megaloblasts in the bone marrow ...
He called it "pernicious anemia" because of the disease's insidious course, and because it was deemed to be untreatable at the time. In 1849, Thomas Addison described the same disease, however Biermer's description was much more comprehensive. Historically, pernicious anemia has also been called "Addison-Biermer disease".
The Museum contains many human specimens that have impacted on the development of medical studies, including Astley Cooper’s ligation of the abdominal aorta, and the original specimens of kidneys, adrenal glands and lymph nodes which led Thomas Hodgkin, Thomas Addison and Richard Bright to describe the medical conditions that bear their names ...
Thomas Addis, pioneer in nephrology; Thomas Addison, first described Addison's disease, pernicious anemia and Addison-Schilder syndrome; William John Adie, first described Adie syndrome and narcolepsy; Arthur Cecil Alport, first identifier of the Alport Syndrome; Kenneth Baillie, intensive care physician; John Hutton Balfour, botanist
During the 1820s and 1830s Bright again worked at Guy's Hospital, teaching, practising and researching medicine. There he worked alongside two other celebrated medical pioneers, Thomas Addison and Thomas Hodgkin. His research into the causes and symptoms of kidney disease led to his identifying what became known as Bright's disease. [3]