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Following is a table of selected substrates, inducers and inhibitors of CYP1A2. Inhibitors of CYP1A2 can be classified by their potency, such as: Strong inhibitor being one that causes at least a 5-fold increase in the plasma AUC values of sensitive substrates metabolized through CYP1A2, or more than 80% decrease in clearance thereof. [18]
Clozapine, imipramine, paracetamol, phenacetin Heterocyclic aryl amines Inducible and CYP1A2 5-10% deficient oxidize uroporphyrinogen to uroporphyrin (CYP1A2) in heme metabolism, but they may have additional undiscovered endogenous substrates. are inducible by some polycyclic hydrocarbons, some of which are found in cigarette smoke and charred ...
CYP1A1 also metabolizes polyunsaturated fatty acids into signaling molecules that have physiological as well as pathological activities. CYP1A1 has monoxygenase activity in that it metabolizes arachidonic acid to 19-hydroxyeicosatetraenoic acid (19-HETE) (see 20-Hydroxyeicosatetraenoic acid) but also has epoxygenase activity in that it metabolizes docosahexaenoic acid to epoxides, primarily ...
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{{Medical cases chart |float = side of the page where the chart will be located (left|center|right|none) [optional, defaults to: right] |barwidth = width of the stacked bars area (thin|medium|wide|auto) [optional, defaults to: medium] |numwidth = max width of the numbers in the right columns (AA or AAAA)←(n|t|m|w|x|d) [suggested, defaults to: mm; see info below] |rowheight = height of each ...
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This template places a location mark on a map. Template parameters Parameter Description Type Status Map name(s) 1 The name of the map to be used; multiple maps can be provided as a list separated by "#". String required Map width width Determines the width of the map in pixels, overriding any default values; do not include "px". For example, use "width=300", not "width=300px". Number optional ...
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