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Vinpocetine has been used in many Asian and European countries for treatment of cerebrovascular disorders such as stroke and dementia for over three decades. [ 3 ] The FDA has tentatively ruled that vinpocetine, due to its synthetic nature and proposed therapeutic uses, is ineligible to be marketed as dietary supplement under the Federal Food ...
Vinpocetine is a synthetic derivative of vincamine used for cerebrovascular diseases and as dietary supplement. [4] Vincamine derivatives have been also studied as anti addictive [ 5 ] and antidiabetic [ 6 ] agents.
The side effects of nicergoline are usually limited to nausea, hot flushes, mild gastric upset, hypotension and dizziness. [6] At high drug dosages, bradycardia, increased appetite, agitation, diarrhea and perspiration were reported. Most of the available literature suggests that the side effects of nicergoline are mild and transient. [2]
Oral MPA has been found to suppress testosterone levels in men by about 30% (from 831 ng/dL to 585 ng/dL) at a dosage of 20 mg/day, by about 45–75% (average 60%; to 150–400 ng/dL) at a dosage of 60 mg/day, [160] [161] [162] and by about 70–75% (from 832 to 862 ng/dL to 214 to 251 ng/dL) at a dosage of 100 mg/day.
The Madagascan periwinkle Catharanthus roseus L. is the source for a number of important natural products, [1] including catharanthine and vindoline [2] and the vinca alkaloids it produces from them: leurosine and the chemotherapy agents vinblastine [3] and vincristine, [4] all of which can be obtained from the plant.
Upon analysis, scientists found that participants who stayed on standard statin treatment for their lifetime increased their quality-adjusted life years by 0.24-0.70, and those on higher-intensity ...
[1] [8] It is used as an aromatase inhibitor to inhibit peripheral estrogen production by mouth at a dosage of 125 mg twice per day (250 mg/day total), without significant suppression of adrenal steroidogenesis at this dosage. [17] Maximal aromatase inhibition is said to occur between dosages of 250 to 500 mg per day. [7] The side effects of AG ...
Vinpocetine inhibits differently the various subtypes of PDE1 (IC 50 from 8 to 50 μm) and it is also able to inhibit PDE7B. It can not be used as a specific tool to investigate the functional role of PDE1 due to its direct activator effects on BK (Ca) channels. [1] Vinpocetine crosses the blood–brain barrier and is taken up by cerebral tissue.