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Pinocytosis. In cellular biology, pinocytosis, otherwise known as fluid endocytosis and bulk-phase pinocytosis, is a mode of endocytosis in which small molecules dissolved in extracellular fluid are brought into the cell through an invagination of the cell membrane, resulting in their containment within a small vesicle inside the cell.
Here, both infectious forms of VACV, mature virion (MV) and enveloped virion (EV), induce their own macropinocytosis by binding to the cell surface and triggering an actin-mediated plasma membrane protrusion that eventually collapses back onto the plasma membrane sealing the attached virion inside a macropinosome, which then goes through a ...
[8] Pinocytosis, which usually occurs from highly ruffled regions of the plasma membrane, is the invagination of the cell membrane to form a pocket, which then pinches off into the cell to form a vesicle (0.5–5 μm in diameter) filled with a large volume of extracellular fluid and molecules within it (equivalent to ~100 CCVs). The filling of ...
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[2] [3] During efferocytosis, the cell membrane of phagocytic cells engulfs the apoptotic cell, forming a large fluid-filled vesicle containing the dead cell. This ingested vesicle is called an efferosome (in analogy to the term phagosome). This process is similar to macropinocytosis.
Triggering receptor expressed on myeloid cells 2 (TREM2) is a protein that in humans is encoded by the TREM2 gene. [ 5 ] [ 6 ] [ 7 ] TREM2 is expressed on macrophages, immature monocyte-derived dendritic cells , osteoclasts , and microglia , [ 8 ] which are immune cells in the central nervous system . [ 9 ]
Cosimo Commisso is a Canadian cell biologist and cancer researcher who has made significant advances in the field of cellular trafficking and cancer metabolism. [1] [2] [3] Among his most notable contributions are the discovery and study of how macropinocytosis supports tumor cell growth and survival by serving as an amino acid supply route in Ras-mutated cancers.
19376 Ensembl ENSG00000109113 ENSMUSG00000002059 UniProt Q9BZG1 P0DI83 Q64008 RefSeq (mRNA) NM_001142624 NM_001142625 NM_001144942 NM_001144943 NM_001256276 NM_001256277 NM_001256278 NM_001256281 NM_031934 NM_001159482 NM_033475 RefSeq (protein) NP_001136096 NP_001136097 NP_001138414 NP_001138415 NP_001243205 NP_001243206 NP_001243207 NP_001243210 NP_114140 NP_001243210.1 NP_001152954 NP ...