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In humans, blastocyst formation begins about five days after fertilization when a fluid-filled cavity opens up in the morula, the early embryonic stage of a ball of 16 cells. The blastocyst has a diameter of about 0.1–0.2 mm and comprises 100-200 cells following 7-8 rounds of cleavage (cell division without cell growth).
Implantation bleeding occurs between 7 and 14 days after fertilization, [57] and is a small amount of light vaginal bleeding or spotting that can occur in early pregnancy due to the blastocyst penetrating the lining of the uterus during implantation.
Human embryology is the study of this development during the first eight weeks after fertilization. The normal period of gestation (pregnancy) is about nine months or 36 weeks. The germinal stage refers to the time from fertilization through the development of the early embryo until implantation is completed in the uterus.
An embryo is the initial stage of development for a multicellular organism.In organisms that reproduce sexually, embryonic development is the part of the life cycle that begins just after fertilization of the female egg cell by the male sperm cell.
At the 16–cell stage the compacted embryo is called a morula. [14] [15] Once the embryo has divided into 16 cells, it begins to resemble a mulberry, hence the name morula (Latin, morus: mulberry). [16] Concomitantly, they develop an inside-out polarity that provides distinct characteristics and functions to their cell-cell and cell-medium ...
After 4–6 days of this intrauterine culture, the embryos are harvested and grown in in vitro culture until the inner cell mass forms “egg cylinder-like structures,” which are dissociated into single cells, and plated on fibroblasts treated with mitomycin-c (to prevent fibroblast mitosis). Clonal cell lines are created by growing up a ...
The germinal stage refers to the time from fertilization, through the development of the early embryo, up until implantation. The germinal stage is over at about 10 days of gestation. [2] The zygote contains a full complement of genetic material with all the biological characteristics of a single human being, and develops into the embryo.
During these cellular divisions, the zygote remains the same size, but the number of cells increase. The morula enters the uterus after three or four days—during which a cavity, called the blastocoel, is formed to produce the blastocyst. [4] Once the blastocyst is formed, it undergoes implantation into the endometrium. [4]