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A box of Plavix. Plavix is marketed worldwide in nearly 110 countries, with sales of US$6.6 billion in 2009. [45] It was the second-top-selling drug in the world in 2007 [46] and was still growing by over 20% in 2007. US sales were US$3.8 billion in 2008. [47] Before the expiry of its patent, clopidogrel was the second best-selling drug in the ...
Warfarin is indicated for the prophylaxis and treatment of venous thrombosis and its extension, pulmonary embolism; [9] prophylaxis and treatment of thromboembolic complications associated with atrial fibrillation and/or cardiac valve replacement; [9] and reduction in the risk of death, recurrent myocardial infarction, and thromboembolic events such as stroke or systemic embolization after ...
In the United States, a boxed warning (sometimes " black box warning ", colloquially) is a type of warning that appears near the beginning of the package insert for certain prescription drugs, so called because the U.S. Food and Drug Administration specifies that it is formatted with a 'box' or border around the text [1] to emphasize it is of ...
Prasugrel is a member of the thienopyridine class of ADP receptor inhibitors, like ticlopidine (trade name Ticlid) and clopidogrel (trade name Plavix). These agents reduce the aggregation ("clumping") of platelets by irreversibly binding to P2Y 12 receptors. Prasugrel inhibits platelet aggregation more rapidly, more consistently, and to a ...
Ranolazine, sold under the brand name Ranexa among others, is a medication used to treat heart related chest pain. [ 5 ] Typically it is used together with other medications when those are insufficient. [ 5 ][ 6 ] Therapeutic benefits appear smaller in females than males. [ 5 ] It is taken by mouth.
View/Edit Human. View/Edit Mouse. P2Y12 is a chemoreceptor for adenosine diphosphate (ADP) [ 5 ][ 6 ] that belongs to the G i class of a group of G protein-coupled (GPCR) purinergic receptors. [ 7 ] This P2Y receptor family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various ...
Precautionary statements are one of the key elements for the labelling of containers under the GHS, along with: [4] an identification of the product; one or more hazard pictograms (where necessary) a signal word – either Danger or Warning – where necessary. hazard statements, indicating the nature and degree of the risks posed by the product.
First-dose phenomenon. The first-dose phenomenon is a sudden and severe fall in blood pressure that can occur when changing from a lying to a standing position the first time that an alpha blocker drug is used [ 1 ] or when resuming the drug after many months off. [ 2 ] This postural hypotension usually happens shortly after the first dose is ...