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BALB/c is an albino, laboratory-bred strain of the house mouse from which a number of common substrains are derived. Now over 200 generations from New York in 1920, BALB/c mice are distributed globally, and are among the most widely used inbred strains used in animal experimentation .
BALB/c laboratory mice. BALB/c is an albino laboratory-bred strain from which a number of common substrains are derived. With over 200 generations bred since 1920, BALB/c mice are distributed globally and are among the most widely used inbred strains used in animal experimentation. [46]
It is the most widely used "genetic background" for genetically modified mice for use as models of human disease. They are the most widely used and best-selling mouse strain due to the availability of congenic strains, easy breeding, and robustness. [1] The median lifespan of C57BL/6 mice is 27–29 months and the maximum lifespan is about 36 ...
Nude mice were the earliest immunodeficient mouse model. These mice primarily produced IgM and had minimal or no IgA. As a result, they did not exhibit a rejection response to allogeneic tissue. Commonly utilized strains included BALB/c-nu, Swiss-nu, NC-nu, and NIH-nu, which were extensively employed in the research of immune diseases and tumors.
That same year, Taconic also started producing BALB/c mice. Taconic became the first commercial provider of the C.B-17 SCID mouse model in 1991. [citation needed] In 1994, Taconic was contracted with the National Institute for Allergy and Infectious Disease to maintain a repository of inbred, congenic, and transgenic mice. [citation needed]
4T1 is a breast cancer cell line derived from the mammary gland tissue of a mouse BALB/c strain. [1] 4T1 cells are epithelial and are resistant to 6-thioguanine. [1] In preclinical research, 4T1 cells have been used to study breast cancer metastasis as they can metastasize to the lung, liver, lymph nodes, brain and bone.
Chromosomes of recombinant inbred strains typically consist of alternating haplotypes of highly variable length that are inherited intact from the parental strains. In the case of a typical mouse recombinant inbred strain made by crossing maternal strain BALB/cBy (C) with paternal strain C57BL/6By (B) called a CXB recombinant inbred strain, a ...
For instance, long-term consumption of a probiotic Lactobacillus strain by BALB/c mice changed gamma-aminobutyric acid expression in brain regions related to emotional processing. This alteration was associated with reduced anxiety and depression-like behaviour. [ 35 ]