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Before immunological pregnancy tests were developed in the 1960s, women relied on urine-based pregnancy tests using animals, ranging from mice to frogs. [1] [2] Advancements in medical technology have enabled women to accurately check their pregnancy status by using 'pee-on-a-stick' pregnancy test kits at home. Before these accessible and ...
The African clawed frog or platanna, Xenopus laevis, was first widely used in laboratories in pregnancy assays in the first half of the 20th century.When human chorionic gonadotropin, a hormone found in substantial quantities in the urine of pregnant women, is injected into a female X. laevis, it induces them to lay eggs.
A later alternative to the rabbit test, known as the "Hogben test", used the African clawed frog, and yielded results without the need to cut the animal open. [6] Modern pregnancy tests continue to operate on the basis of testing for the presence of the hormone hCG in the blood or urine, but they no longer require the use of a live animal.
In general, it's best to wait until you've missed your period, and to take the test first thing in the morning. Learn how timing impacts accuracy from experts.
This makes the species even more unique, as PLOS One said, because other frogs that skip the egg step typically give birth to froglets, or baby frogs, but these frogs still give birth to tadpoles.
This test, known as the frog test, was used throughout the world from the 1930s to 1960s, with Xenopus frogs being exported in great numbers. [38] [39] Shapiro's advisor, Lancelot Hogben, claimed to have developed the pregnancy test himself, but this was refuted by both Shapiro and Zwarenstein in a letter to the British Medical Journal.
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