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Heparin-induced thrombocytopenia (HIT) is due to an immune system reaction against the anticoagulant drug heparin (or its derivatives). [1] Though it is named for associated low platelet counts, HIT is strongly associated with risk of venous and arterial thrombosis. [19]
Some thrombotic and coagulopathic disorders are disseminated intravascular coagulation (DIC), [6] hypercoagulable states (like antiphospholipid antibodies), thrombotic thrombocytopenic purpura (TTP), warfarin-induced skin necrosis, heparin-induced thrombocytopenia, and paroxysmal nocturnal hemoglobinuria.
ICD-10-PCS: I80-I82: ... alternative to heparin in those developing heparin-induced thrombocytopenia [41] [24 ... The therapeutic effects of warfarin may be decreased ...
One common definition of thrombocytopenia requiring emergency treatment is a platelet count below 50,000/μL. [5] Thrombocytopenia can be contrasted with the conditions associated with an abnormally high level of platelets in the blood – thrombocythemia (when the cause is unknown), and thrombocytosis (when the cause is known). [6] [7]
Coagulopathy (also called a bleeding disorder) is a condition in which the blood's ability to coagulate (form clots) is impaired. [1] This condition can cause a tendency toward prolonged or excessive bleeding (bleeding diathesis), which may occur spontaneously or following an injury or medical and dental procedures.
Warfarin should not be given to people with heparin-induced thrombocytopenia until platelet count has improved or normalised. [39] Warfarin is usually best avoided in people with protein C or protein S deficiency, as these thrombophilic conditions increase the risk of skin necrosis, which is a rare but serious side effect associated with ...
Many cases of congenital dysfibrinogenemia are asymptomatic. Since manifestations of the disorder generally occur in early adulthood or middle-age, younger individuals with a gene mutation causing it may not have had time to develop symptoms while previously asymptomatic individuals of advanced age with such a mutation are unlikely to develop symptoms.
[54] [55] Long-term warfarin and heparin usage have also been linked to osteoporosis. [56] [45] Another potentially severe complication associated with heparin use is called heparin-induced thrombocytopenia (HIT). [57] There are two distinct types: HIT 1) immune-mediated and 2) non-immune-mediated. [57]