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Sildenafil could also cause an increased risk of heart attack or other heart problems. If you have an irregular heartbeat, hearing loss, vision loss, an allergic reaction, Peyronie’s disease, or ...
Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
Sildenafil, sold under the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. [ 4 ] [ 8 ] It is also sometimes used off-label for the treatment of certain symptoms in secondary Raynaud's phenomenon . [ 9 ]
How to Use Viagra for Best Results. Viagra is great as an ED treatment, but taking it in particular conditions can make it even more effective. To get the best results from Viagra when treating ...
Sildenafil is most commonly prescribed to be taken one time per day in doses between 25 and 100 mg for ED. Your healthcare provider will determine the best dosage for you based on a number of factors.
Sildenafil did not prove effective for coronary heart disease but an interesting side effect was discovered, a penile erection. That side effect soon became the main field of investigation. [23] The inhibitor is highly selective for the PDE5 family. [22] Sildenafil is a prototype of PDE5 inhibitors that Pfizer launched as Viagra.
For example, a small study of 20 people that looked into Viagra’s effect on refractory time found that a standard 100mg dose of sildenafil citrate reduced the average male post-intimacy recovery ...
Sildenafil, Tadalafil, Vardenafil [13] Erectile dysfunction ( ED ), also referred to as impotence , is a form of sexual dysfunction in males characterized by the persistent or recurring inability to achieve or maintain a penile erection with sufficient rigidity and duration for satisfactory sexual activity .