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While the loop of Henle makes the medulla of the kidney salty, the collecting duct regulates the permeability of water that could be reabsorbed to such salty environment. The saltier the medulla, the more water can be reabsorbed from the pre-urine in collecting duct; before it becomes urine.
The collecting duct system of the kidney consists of a series of tubules and ducts that physically connect nephrons to a minor calyx or directly to the renal pelvis.The collecting duct participates in electrolyte and fluid balance through reabsorption and excretion, processes regulated by the hormones aldosterone and vasopressin (antidiuretic hormone).
The collecting duct system begins in the renal cortex and extends deep into the medulla. As the urine travels down the collecting duct system, it passes by the medullary interstitium which has a high sodium concentration as a result of the loop of Henle's countercurrent multiplier system. [1]: 67
Loop of Henle Distal tubule Collecting duct; Glucose: If glucose is not reabsorbed by the kidney, it appears in the urine, in a condition known as glycosuria. This is associated with diabetes mellitus. [2] reabsorption (almost 100%) via sodium-glucose transport proteins [3] and GLUT (basolateral). – – – Oligopeptides, proteins, and amino ...
The medullary interstitium is the tissue surrounding the loop of Henle in the medulla. It functions in renal water reabsorption by building up a high hypertonicity, which draws water out of the thin descending limb of the loop of Henle and the collecting duct system.
Sodium is reabsorbed in the thick ascending limb of loop of Henle, by Na-K-2Cl symporter and Na-H antiporter.It goes against its chemical driving force, but the high electrical driving force renders the overall electrochemical driving force positive anyway, availing some sodium to diffuse passively either the transcellular or paracellular way.
The loop of Henle is the most prominent feature of the mammalian kidney. These loops provide the most efficient way to reabsorb water and create concentrated urine, allowing mammals to save water in their bodies. [138] After passing through the loop of Henle, the fluid becomes hypertonic relative to the blood plasma. [139]
loop of Henle Distal convoluted tubule Collecting duct system; S1 S2 S3 descending limb: thin ascending limb: thick ascending limb: connecting tubule: initial collecting tubule cortical collecting ducts medullary collecting ducts reabsorption (% compared to filtered amount) 50 [1] 50 secretion (% compared to filtered amount) 50 [1] reabsorption ...