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Gout causes painful swelling, typically only impacting one joint. Its symptoms can come and go. Periods when gout symptoms are more severe are called gout flares or gout attacks.
Rates of gout approximately doubled between 1990 and 2010. [17] This rise is believed to be due to increasing life expectancy, changes in diet and an increase in diseases associated with gout, such as metabolic syndrome and high blood pressure. [25] Factors that influence rates of gout include age, race, and the season of the year.
Creatine is produced by the enzyme guanidinoacetate methyltransferase (GAMT). After production in the liver and kidneys, creatine is transported to organs and tissues with high energy demands, most commonly the brain and skeletal muscles. In addition to endogenous production, creatine can be obtained from dietary sources or supplementation.
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Without treatment, tophi may develop on average about ten years after the onset of gout, although their first appearance can range from three to forty-two years. The development of gouty tophi can also limit joint function and cause bone destruction, leading to noticeable disabilities, especially when gout cannot successfully be treated. [ 2 ]
What causes gout? The condition is caused by a buildup of uric acid in the body. Uric acid forms when the body breaks down purines, a chemical compound that cells use to form DNA and RNA.
Do not prescribe allopurinol for acute gout flair. Wait until they are six weeks resolved to initiate that, otherwise you can cause an acute flare/worsening of the gout. However, they are already on allopurinol, continue it.
The post Managing Out-of-Control Chronic Gout: Going Beyond Oral Treatments appeared first on Reader's Digest. Do you sometimes have severe, unexplained pain in your joints, particularly in your ...
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