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However, because of the multigene involvement in autism, the MECP2 gene has only been identified as a vulnerability factor in autism. [63] The most current model illustrating MECP2 is known as the transcriptional activator model. Another potential molecular convergence involves the early growth response gene-2 (EGR2). [60]
The founders comprised a small group of parents, including two psychiatrists, a lawyer, a CPA and a chemistry professor. NAAR raised money to provide research grants focusing on autism, and has committed an excess of $20 million to over 200 autism research projects, fellowships and collaborative programs - more than any other non-governmental ...
Discrete trial training is rooted in the hypothesis of Charles Ferster that autism was caused in part by a person's inability to react appropriately to "social reinforcers", such as praise or criticism. Lovaas's early work concentrated on showing that it was possible to strengthen autistic people's responses to these social reinforcers, but he ...
This is a list of investigational autism and pervasive developmental disorder drugs, or drugs that are currently under development for clinical use in the treatment of autistic spectrum disorders and/or other pervasive developmental disorders but are not yet approved.
The amygdala, cerebellum, and many other brain regions have been implicated in autism. [15]Unlike some brain disorders which have clear molecular hallmarks that can be observed in every affected individual, such as Alzheimer's disease or Parkinson's disease, autism does not have a unifying mechanism at the molecular, cellular, or systems level.
The University of North Carolina TEACCH Autism Program creates and disseminates community-based services, training programs, and research for individuals of all ages and skill levels with autism spectrum disorder (ASD), to enhance the quality of life for them and their families across the lifespan. [1]
Pivotal response treatment is a naturalistic intervention model derived from the principles of applied behavior analysis.Rather than target individual behaviors one at a time, PRT targets pivotal areas of a child's development such as motivation, [3] responsiveness to multiple cues, [4] self-management, and social initiations. [5]
In a study conducted with the plasmas of children displaying classic-onset autism, the concentration of MAP6 protein levels were lower than that of healthy children. [17] In MAP6 KO mice conducted in the same study, there was a reduction in pre-synaptic glutamate vesicle density. Low glutamate release levels are common in autism, which could ...