Search results
Results from the WOW.Com Content Network
About 10% of individuals with BPDCN present with a leukemia-like disease, [4] i.e. they exhibit circulating malignant pDC, anemia, thrombocytopenia, and/or leukopenia due to extensive malignant pDC infiltrations in the bone marrow. [4] A leukemic phase of the disease is a common feature of end stage and post-therapy relapsing BPDCN. [2]
This leads to neutropenia, anemia, and thrombocytopenia. [22] Other symptoms can arise from the infiltration of malignant cells into parts of the body, such as the gingiva and skin. [22] Many cells develop mutations in genes that affect epigenetics, such as DNA methylation. [3] When these mutations occur, it is likely in the early stages of AML ...
Multiple myeloma is the result of a multi-step malignant transformation, and almost universally originates from the pre-malignant stage monoclonal gammopathy of undetermined significance (MGUS). As MGUS evolves into MM, another pre-stage of the disease is reached, known as smoldering myeloma (SMM). [15]
Of the sixteen separate sites the body compared, leukemia was the 12th most common class of neoplastic disease and the 11th most common cause of cancer-related death. [79] Leukemia occurs more commonly in the developed world .
These conditions were lumped together with other diseases under the term "refractory anemia". The first description of "preleukemia" as a specific entity was published in 1953 by Block et al. [ 60 ] The early identification, characterization and classification of this disorder were problematical, and the syndrome went by many names until the ...
While uncommon in solid tumors, chromosomal translocations are a common cause of these diseases. This commonly leads to a different approach in diagnosis and treatment of hematological malignancies. Hematological malignancies are malignant neoplasms ("cancer"), and they are generally treated by specialists in hematology and/or oncology.
Myeloproliferative neoplasms (MPNs) are a group of rare blood cancers in which excess red blood cells, white blood cells or platelets are produced in the bone marrow. Myelo refers to the bone marrow , proliferative describes the rapid growth of blood cells and neoplasm describes that growth as abnormal and uncontrolled.
Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the development of large numbers of immature lymphocytes. [1] Symptoms may include feeling tired, pale skin color, fever, easy bleeding or bruising, enlarged lymph nodes, or bone pain. [1]